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Jennifer Martindale, BS; Michael D. Geschwind, MD, PhD; Stephen De Armond, MD, PhD; Geoffrey Young, MD; W. P. Dillon, MD; Roland Henry, PhD; Jane H. Uyehara-Lock, MD; David A. Gaskin, MD; Bruce L. Miller, MD

Arch Neurol. 2003;60:767-770.

Background  The determination of the form of prion disease and early diagnosis are important for prognostic, public health, and epidemiologic reasons.

Objective  To describe a patient with sporadic Creutzfeldt-Jakob disease (sCJD) who had a clinical history and initial electroencephalogram and magnetic resonance imaging findings consistent with variant CJD (vCJD).

Results  Results of a repeated electroencephalogram were suggestive of sCJD, and a subsequent brain biopsy confirmed this diagnosis.

Conclusions  This case cautions against relying solely on T2- and diffusion-weighted pulvinar hyperintensity and clinical features to differentiate between vCJD and sCJD, and further supports established diagnostic criteria for vCJD.

From the Departments of Neurology (Ms Martindale and Drs Geschwind and Miller), Radiology (Drs Young, Henry, and Dillon), and Pathology (Drs De Armond, Uyehara-Lock, and Gaskin), University of California– San Francisco, San Francisco.

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