 |
|
Parkinsonianlike Signs and Risk of Incident Alzheimer Disease in Older Persons
Robert S. Wilson, PhD;
Julie A. Schneider, MD;
Julia L. Bienias, ScD;
Denis A. Evans, MD;
David A. Bennett, MD
Arch Neurol. 2003;60:539-544.
Background Parkinsonianlike signs are common in older persons, but little is known about how their severity or rate of progression is related to the development of Alzheimer disease (AD) or decline in cognition.
Objective To examine the association of progression of parkinsonianlike signs with incident AD and cognitive decline.
Design Longitudinal cohort study.
Participants and Setting For up to 8 years, 824 older Catholic clergy members without clinical evidence of AD or Parkinson disease at baseline underwent annual clinical evaluations that included a modified version of the Unified Parkinson's Disease Rating Scale (UPDRS), detailed cognitive function testing, and clinical classification of AD.
Main Outcome Measures Clinically diagnosed AD and change in global and specific measures of cognitive function.
Results During an average of 4.6 years of observation, 114 persons developed AD. The global UPDRS score increased in 79% of participants, who were divided into tertiles with the least, moderate, or most rapid progression. We examined the relationship of progression to disease risk in a proportional hazards model that controlled for baseline global UPDRS and demographic variables. Compared with the 21% without progression, risk of AD more than doubled in the subgroup with the least progression (P = .08), more than tripled in the moderate subgroup (P = .02), and increased more than 8-fold in the subgroup with the most rapid progression (P<.001). This effect was mainly due to worsening gait and rigidity. Rate of change on the global UPDRS measure was inversely correlated with rate of change on a global measure of cognitive function (r = -0.64).
Conclusion Progression of parkinsonianlike signs in old age is associated with decline in cognitive function and the development of AD.
From the Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging (Drs Wilson, Schneider, Bienias, Evans, and Bennett) and the Departments of Neurological Sciences (Drs Wilson, Schneider, and Bennett), Internal Medicine (Drs Bienias and Evans), and Psychology (Dr Wilson), Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Relation of cognitive activity to risk of developing Alzheimer disease
Wilson et al.
Neurology 2007;69:1911-1920.
ABSTRACT
| FULL TEXT
Mild Parkinsonian Signs and Plasma Homocysteine Concentration in Community-Dwelling Elderly Individuals
Louis et al.
Arch Neurol 2007;64:1646-1651.
ABSTRACT
| FULL TEXT
Conscientiousness and the Incidence of Alzheimer Disease and Mild Cognitive Impairment
Wilson et al.
Arch Gen Psychiatry 2007;64:1204-1212.
ABSTRACT
| FULL TEXT
Frailty is Associated With Incident Alzheimer's Disease and Cognitive Decline in the Elderly
Buchman et al.
Psychosom. Med. 2007;69:483-489.
ABSTRACT
| FULL TEXT
Motor Dysfunction in Mild Cognitive Impairment and the Risk of Incident Alzheimer Disease
Aggarwal et al.
Arch Neurol 2006;63:1763-1769.
ABSTRACT
| FULL TEXT
Blood pressure and lower limb function in older persons.
Shah et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2006;61:839-843.
ABSTRACT
| FULL TEXT
History of vascular disease and mild parkinsonian signs in community-dwelling elderly individuals.
Louis and Luchsinger
Arch Neurol 2006;63:717-722.
ABSTRACT
| FULL TEXT
Hallucinations and Mortality in Alzheimer Disease
Wilson et al.
AJGP 2005;13:984-990.
ABSTRACT
| FULL TEXT
Change in body mass index and risk of incident Alzheimer disease
Buchman et al.
Neurology 2005;65:892-897.
ABSTRACT
| FULL TEXT
Diagnosis and treatment of Alzheimer's disease
Desai and Grossberg
Neurology 2005;64:S34-S39.
ABSTRACT
| FULL TEXT
Association between mild parkinsonian signs and mild cognitive impairment in a community
Louis et al.
Neurology 2005;64:1157-1161.
ABSTRACT
| FULL TEXT
Functional Correlates and Prevalence of Mild Parkinsonian Signs in a Community Population of Older People
Louis et al.
Arch Neurol 2005;62:297-302.
ABSTRACT
| FULL TEXT
Diabetes mellitus and progression of rigidity and gait disturbance in older persons
Arvanitakis et al.
Neurology 2004;63:996-1001.
ABSTRACT
| FULL TEXT
Parkinsonian Signs in Older People in a Community-Based Study: Risk of Incident Dementia
Louis et al.
Arch Neurol 2004;61:1273-1276.
ABSTRACT
| FULL TEXT
Personality and Mortality in Old Age
Wilson et al.
J. Gerontol. B Psychol. Sci. Soc. Sci. 2004;59:P110-P116.
ABSTRACT
| FULL TEXT
Some Parkinson's Patients At High Alzheimer's Risk
Rosack
Psychiatr. News 2003;38:25-25.
FULL TEXT
|
