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Clinical Exacerbation of Multiple Sclerosis Following Radiotherapy
Colleen B. Murphy, MD, BSc;
Stanley A. Hashimoto, MD, FRCPC;
Douglas Graeb, MD, FRCPC;
Brian A. Thiessen, MD, FRCPC
Arch Neurol. 2003;60:273-275.
Background Radiation of the central nervous system in patients with demyelinating disease may have deleterious effects.
Objective To describe a 30-year-old woman with multiple sclerosis who developed an attack of demyelination 2 months following radiotherapy for a parotid malignancy.
Results Magnetic resonance imaging demonstrated new hyperintense lesions that corresponded to both the localization of the patient's symptoms and to the area defined by the 50% isodose radiation field.
Conclusion Radiation treatment likely triggered an exacerbation of multiple sclerosis.
From the Division of Neurology, Department of Medicine, University of British Columbia (UBC) (Drs Murphy and Thiessen); the Multiple Sclerosis Clinic, Vancouver Hospital and Health Sciences Center, UBC Hospital (Dr Hashimoto); the Division of Neurology (Dr Hashimoto) and Department of Radiology (Dr Graeb), Vancouver General Hospital; and the Department of Medical Oncology, British Columbia Cancer Agency (Dr Thiessen), Vancouver, British Columbia.
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