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Colleen B. Murphy, MD, BSc; Stanley A. Hashimoto, MD, FRCPC; Douglas Graeb, MD, FRCPC; Brian A. Thiessen, MD, FRCPC

Arch Neurol. 2003;60:273-275.

Background  Radiation of the central nervous system in patients with demyelinating disease may have deleterious effects.

Objective  To describe a 30-year-old woman with multiple sclerosis who developed an attack of demyelination 2 months following radiotherapy for a parotid malignancy.

Results  Magnetic resonance imaging demonstrated new hyperintense lesions that corresponded to both the localization of the patient's symptoms and to the area defined by the 50% isodose radiation field.

Conclusion  Radiation treatment likely triggered an exacerbation of multiple sclerosis.

From the Division of Neurology, Department of Medicine, University of British Columbia (UBC) (Drs Murphy and Thiessen); the Multiple Sclerosis Clinic, Vancouver Hospital and Health Sciences Center, UBC Hospital (Dr Hashimoto); the Division of Neurology (Dr Hashimoto) and Department of Radiology (Dr Graeb), Vancouver General Hospital; and the Department of Medical Oncology, British Columbia Cancer Agency (Dr Thiessen), Vancouver, British Columbia.

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