 |
 |

Antioxidant Vitamin Intake and Risk of Alzheimer Disease
Jose A. Luchsinger, MD;
Ming-Xin Tang, PhD;
Steven Shea, MD;
Richard Mayeux, MD
Arch Neurol. 2003;60:203-208.
Background The generation of oxygen free radicals is involved in the pathogenesis of Alzheimer disease (AD).
Objective To determine whether the intake of antioxidant vitamins decreases the risk of AD.
Methods We investigated the relationship between AD and the intake of carotenes, vitamin C, and vitamin E in 980 elderly subjects in the Washington Heights-Inwood Columbia Aging Project who were free of dementia at baseline and were followed for a mean time of 4 years. Semiquantitative food frequency questionnaires were administered between baseline and the first follow-up visit. Cox proportional hazards regression models were conducted with quartiles of each vitamin intake as the exposure of interest and incident AD as the outcome, adjusted for age, level of education, sex, APOE 4 status, ethnicity, and smoking.
Results There were 242 incident cases of AD in 4023 person-years of follow-up (6 per 100 person-years). Intake of carotenes and vitamin C, or vitamin E in supplemental or dietary (nonsupplemental) form or in both forms, was not related to a decreased risk of AD. Trend tests for the association between quartiles of total intake of vitamins C and E also were not significant.
Conclusion Neither dietary, supplemental, nor total intake of carotenes and vitamins C and E was associated with a decreased risk of AD in this study.
From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Drs Luchsinger, Tang, and Mayeux), the Gertrude H. Sergievsky Center (Dr Mayeux), the Division of General Medicine, Department of Medicine (Drs Luchsinger and Shea), and the Departments of Neurology and Psychiatry (Dr Mayeux), College of Physicians and Surgeons, and the Divisions of Biostatistics (Dr Tang) and Epidemiology (Drs Mayeux and Shea), Joseph P. Mailman School of Public Health, Columbia University, New York, NY.
CiteULike Connotea Del.icio.us Digg Reddit Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Mediterranean Diet and Mild Cognitive Impairment
Scarmeas et al.
Arch Neurol 2009;66:216-225.
ABSTRACT
| FULL TEXT
Dementia Prevention: Methodological Explanations for Inconsistent Results
Coley et al.
Epidemiol Rev 2008;30:35-66.
ABSTRACT
| FULL TEXT
Plasma tocopherols and risk of cognitive impairment in an elderly Italian cohort
Ravaglia et al.
Am. J. Clin. Nutr. 2008;87:1306-1313.
ABSTRACT
| FULL TEXT
Mediterranean diet and Alzheimer disease mortality
Scarmeas et al.
Neurology 2007;69:1084-1093.
ABSTRACT
| FULL TEXT
Smoking as a Risk Factor for Dementia and Cognitive Decline: A Meta-Analysis of Prospective Studies
Anstey et al.
Am J Epidemiol 2007;166:367-378.
ABSTRACT
| FULL TEXT
Flavonoid Intake and Cognitive Decline over a 10-Year Period
Letenneur et al.
Am J Epidemiol 2007;165:1364-1371.
ABSTRACT
| FULL TEXT
Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis
Shin et al.
Mol. Pharmacol. 2007;71:965-975.
ABSTRACT
| FULL TEXT
Serum {alpha}-tocopherol, concurrent and past vitamin E intake, and mild cognitive impairment
Dunn et al.
Neurology 2007;68:670-676.
ABSTRACT
| FULL TEXT
A Randomized Trial of Vitamin E Supplementation and Cognitive Function in Women
Kang et al.
Arch Intern Med 2006;166:2462-2468.
ABSTRACT
| FULL TEXT
Mediterranean Diet, Alzheimer Disease, and Vascular Mediation
Scarmeas et al.
Arch Neurol 2006;63:1709-1717.
ABSTRACT
| FULL TEXT
Dementia and Alzheimer's Disease in Community-Dwelling Elders Taking Vitamin C and/or Vitamin E
Fillenbaum et al.
The Annals of Pharmacotherapy 2005;39:2009-2014.
ABSTRACT
| FULL TEXT
Vitamin C and Vitamin E for Alzheimer's Disease
Boothby and Doering
The Annals of Pharmacotherapy 2005;39:2073-2079.
ABSTRACT
| FULL TEXT
Synergistic amplification of {beta}-amyloid- and interferon-{gamma}-induced microglial neurotoxic response by the senile plaque component chromogranin A
Twig et al.
Am. J. Physiol. Cell Physiol. 2005;288:C169-C175.
ABSTRACT
| FULL TEXT
Impact of antioxidants, zinc, and copper on cognition in the elderly: A randomized, controlled trial
Age-Related Eye Disease Study Research Group
Neurology 2004;63:1705-1707.
ABSTRACT
| FULL TEXT
Midlife Dietary Intake of Antioxidants and Risk of Late-Life Incident Dementia: The Honolulu-Asia Aging Study
Laurin et al.
Am J Epidemiol 2004;159:959-967.
ABSTRACT
| FULL TEXT
Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements: The Cache County Study
Zandi et al.
Arch Neurol 2004;61:82-88.
ABSTRACT
| FULL TEXT
Antioxidants don't prevent dementia
BMJ 2003;326:.
FULL TEXT
|