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Jose A. Luchsinger, MD; Ming-Xin Tang, PhD; Steven Shea, MD; Richard Mayeux, MD

Arch Neurol. 2003;60:203-208.

Background  The generation of oxygen free radicals is involved in the pathogenesis of Alzheimer disease (AD).

Objective  To determine whether the intake of antioxidant vitamins decreases the risk of AD.

Methods  We investigated the relationship between AD and the intake of carotenes, vitamin C, and vitamin E in 980 elderly subjects in the Washington Heights-Inwood Columbia Aging Project who were free of dementia at baseline and were followed for a mean time of 4 years. Semiquantitative food frequency questionnaires were administered between baseline and the first follow-up visit. Cox proportional hazards regression models were conducted with quartiles of each vitamin intake as the exposure of interest and incident AD as the outcome, adjusted for age, level of education, sex, APOE 4 status, ethnicity, and smoking.

Results  There were 242 incident cases of AD in 4023 person-years of follow-up (6 per 100 person-years). Intake of carotenes and vitamin C, or vitamin E in supplemental or dietary (nonsupplemental) form or in both forms, was not related to a decreased risk of AD. Trend tests for the association between quartiles of total intake of vitamins C and E also were not significant.

Conclusion  Neither dietary, supplemental, nor total intake of carotenes and vitamins C and E was associated with a decreased risk of AD in this study.

From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Drs Luchsinger, Tang, and Mayeux), the Gertrude H. Sergievsky Center (Dr Mayeux), the Division of General Medicine, Department of Medicine (Drs Luchsinger and Shea), and the Departments of Neurology and Psychiatry (Dr Mayeux), College of Physicians and Surgeons, and the Divisions of Biostatistics (Dr Tang) and Epidemiology (Drs Mayeux and Shea), Joseph P. Mailman School of Public Health, Columbia University, New York, NY.

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