This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (21)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Neurocutaneous Diseases  • Radiologic Imaging  • Magnetic Resonance Imaging  • Genetic Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Floor E. Jansen, MD; Kees P. J. Braun, MD, PhD; Onno van Nieuwenhuizen, MD, PhD; Geertjan Huiskamp, PhD; Koen L. Vincken, PhD; Alexander C. van Huffelen, MD, PhD; Jeroen van der Grond, PhD

Arch Neurol. 2003;60:1580-1584.

Background  Patients with tuberous sclerosis complex and drug-resistant epilepsy may be considered candidates for epilepsy surgery. This demands the unambiguous demonstration of the epileptogenicity of one of the tubers.

Objective  To test whether diffusion-weighted magnetic resonance imaging enables differentiation of epileptogenic tubers from inert ones.

Methods  In 4 patients with clear unifocal interictal spike activity, fluid-attenuated inversion recovery and diffusion-weighted magnetic resonance imaging were performed. Apparent diffusion coefficient maps were calculated in the identified epileptogenic tuber and compared withthose in nonepileptogenic tubers and regions of normal-appearing cortex.

Results  A significant increase in the apparent diffusion coefficient was found in the epileptogenic tubers. Furthermore, the apparent diffusion coefficient of the nonepileptogenic tubers was significantly higher than the trace apparent diffusion coefficient of regions of normal-appearing cortex.

Conclusion  Diffusion-weighted magnetic resonance imaging may be of clinical importance for the identification of epileptogenic tubers in patients with tuberous sclerosis and intractable epilepsy.

From the Departments of Child Neurology (Drs Jansen, Braun, and van Nieuwenhuizen) and Clinical Neurophysiology (Drs Huiskamp and van Huffelen) and the Image Sciences Institute (Drs Vincken and van der Grond), University Medical Center, Utrecht, the Netherlands.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Characteristics of Abnormal Diffusivity in Normal-Appearing White Matter Investigated with Diffusion Tensor MR Imaging in Tuberous Sclerosis Complex
Makki et al.
Am. J. Neuroradiol. 2007;28:1662-1667.
ABSTRACT | FULL TEXT  

Interictal diffusion MRI in partial epilepsies explored with intracerebral electrodes
Thivard et al.
Brain 2006;129:375-385.
ABSTRACT | FULL TEXT  

Identification of candidates for epilepsy surgery in patients with tuberous sclerosis
Lachhwani et al.
Neurology 2005;64:1651-1654.
ABSTRACT | FULL TEXT  

Epilepsy Surgery Outcome in Children With Tuberous Sclerosis Complex Evaluated With {alpha}-[11C]Methyl-L-Tryptophan Positron Emission Tomography (PET)
Kagawa et al.
J Child Neurol 2005;20:429-438.
ABSTRACT  

Managing Epilepsy in Tuberous Sclerosis Complex
Thiele
J Child Neurol 2004;19:680-686.
ABSTRACT