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West Nile Virus Encephalitis Involving the Substantia Nigra
Neuroimaging and Pathologic Findings With Literature Review
Carol Mae Bosanko, MD;
John Gilroy, MD;
Ay-Ming Wang, MD;
William Sanders, MD;
Mohanpal Dulai, MD;
Jon Wilson, MD;
Keith Blum, DO
Arch Neurol. 2003;60:1448-1452.
West Nile virus has become a medically important arbovirus in the continental United States with its debut in 1999 in the New York City area. We present neuroimaging features and pathologic findings in 2 patients who were severely affected out of the more that 100 documented cases at our institution. Both patients showed striking involvement of the substantia nigra, a finding not previously reported for West Nile virus.
From the Departments of Diagnostic Radiology (Drs Bosanko, Wang, and Sanders), Neurology (Dr Gilroy), Anatomic Pathology (Drs Dulai and Wilson), and Neurosurgery (Dr Blum), William Beaumont Hospital, Royal Oak, Mich.
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