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Part 1

Oscar L. Lopez, MD; William J. Jagust; Steven T. DeKosky, MD; James T. Becker, PhD; Annette Fitzpatrick, PhD; Corinne Dulberg, PhD; John Breitner, MD; Constantine Lyketsos, MD; Beverly Jones, MD; Claudia Kawas, MD; Michelle Carlson, PhD; Lewis H. Kuller, MD

Arch Neurol. 2003;60:1385-1389.

Objective  To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study.

Design  The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort.

Setting  Multicenter population study.

Patients  We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI.

Main Outcome Measures  The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center (n = 927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits–type.

Results  The overall prevalence of MCI was 19% (465 of 2470 participants); prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits–type was 16%.

Conclusions  Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogenous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits–type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions.

From the Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pa (Drs Lopez, DeKosky, and Becker); Department of Neurology, University of California, Davis, Sacramento (Mr Jagust); Departments of Biostatistics (Dr Dulberg) and Epidemiology (Dr Fitzpatrick), University of Washington, Seattle; Departments of Aging and Health and Mental Hygiene, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (Drs Breitner and Carlson); Departments of Psychiatry (Dr Lyketsos) and Neurology (Dr Kawas), The Johns Hopkins University, Baltimore; Department of Psychiatry, Wake-Forest University, Winston-Salem, NC (Dr Jones); and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (Dr Kuller). Dr Breitner is now with the Geriatric Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle. Dr Kawas is now with the Department of Neurology, University of California, Irvine.

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Risk Factors for Mild Cognitive Impairment in the Cardiovascular Health Study Cognition Study: Part 2
Oscar L. Lopez, William J. Jagust, Corinne Dulberg, James T. Becker, Steven T. DeKosky, Annette Fitzpatrick, John Breitner, Constantine Lyketsos, Beverly Jones, Claudia Kawas, Michelle Carlson, and Lewis H. Kuller
Arch Neurol. 2003;60(10):1394-1399.
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