Autopsy-Proven, Sporadic Pick Disease With Onset at Age 25 Years
Landon W. Coleman, MD;
Kathleen B. Digre, MD;
Gary M. Stephenson, MD;
Jeannette J. Townsend, MD
Arch Neurol. 2002;59:856-859.
Context Pick disease is uncommon and accounts for less than 2% of adult-onset
dementias. Reports of Pick disease in young adults have apparently increased
in the last decade.
Objective To document the presentation and course of a patient with tau-positive
Pick disease presenting at an extremely young age.
Setting A university hospital.
Patient A white woman with cognitive impairment that began at age 25 years.
She experienced progressive dementia over an 8-year period with radiographic
evidence of severe cerebral atrophy of the frontotemporal lobes. Autopsy findings
confirmed the diagnosis of Pick disease characterized by tau-positive Pick
bodies in the neurons of the fascia dentata.
Conclusion Pick disease should be considered in the differential diagnosis of young
adults presenting with behavioral symptoms, especially those of frontal impairment.
From the Departments of Pathology (Drs Coleman and Townsend), Neurology
(Dr Digre), and Psychiatry (Dr Stephenson), University of Utah Health Sciences
Center, Salt Lake City.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
RELATED ARTICLE
Archives of Neurology Reader's Choice: Continuing Medical Education
Arch Neurol. 2002;59(5):878-880.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Autopsy proven sporadic frontotemporal dementia due to microvacuolar-type histology, with onset at 21 years of age
Snowden et al.
J. Neurol. Neurosurg. Psychiatry 2004;75:1337-1339.
ABSTRACT
| FULL TEXT
|
