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Familial Aggregation of Parkinson Disease
A Comparative Study of Early-Onset and Late-Onset Disease
Haydeh Payami, PhD;
Sepideh Zareparsi, PhD;
Dora James, BS;
John Nutt, MD
Arch Neurol. 2002;59:848-850.
Context It is unclear whether late-onset Parkinson disease (PD), which is the
most typical and most common form of the disease, has a familial component.
Evidence for familial aggregation is key to whether research should focus
on gene discovery or search for environmental factors.
Objective To investigate familial aggregation of early-onset and late-onset PD
separately.
Methods Using survival methods, age-specific risk of PD was calculated and compared
for 525 parents and siblings of 117 patients with early-onset PD, 1642 parents
and siblings of 343 patients with late-onset PD, and 522 parents and siblings
of 114 controls. The index patients were ascertained from a movement disorder
clinic. Spouses and friends served as controls.
Results Compared with the relatives of controls, age-specific risk of PD was
increased 7.76-fold in the relatives of patients with early-onset disease
(P<.001) and 2.95-fold in the relatives of those
with late-onset disease (P = .02).
Conclusions Late-onset PD has a significant familial component. The magnitude of
recurrence risk to relatives suggests a genetic etiology, without ruling out
the possibility of a coexisting environmental component.
From the Department of Neurology, Oregon Health Sciences University,
Portland (Drs Payami, Zareparsi, and Nutt, and Ms James); and the W. K. Kellogg
Eye Center, University of Michigan, Ann Arbor (Dr Zareparsi).
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