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Familial Kleine-Levin Syndrome
Two Siblings With Unusually Long Hypersomnic Spells
Joshua D. Katz, MD;
Allan H. Ropper, MD
Arch Neurol. 2002;59:1959-1961.
Kleine-Levin syndrome is a rare, sporadic disorder, with discrete spells of hypersomnolence occurring during adolescence, variously accompanied by megaphagia, behavioral changes, psychosis, and mild autonomic symptoms. Familial cases have not previously been reported. We describe 2 siblings who shared uncharacteristically prolonged episodes of hypersomnolence, and the HLA-DR2 haplotype. In one patient, levels of cerebrospinal fluid orexin (hypocretin) during an attack were normal. The presence of an increased sleep drive, despite the occurrence of large amounts of ostensibly restorative sleep, suggests the possible existence of a disorder of sleep satiety.
From the Neurology Service, St Elizabeth's Medical Center, and Tufts University School of Medicine, Boston, Mass.
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