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An Analysis From the German Stroke Data Bank

Christian Weimar, MD; Klaus Kraywinkel, MD; Joachim Rödl, MD; André Hippe, MD; Lutz Harms, MD; Antje Kloth, MD; Hans-Christoph Diener, MD; for the German Stroke Data Bank Collaborators

Arch Neurol. 2002;59:1584-1588.

Context  A transient ischemic attack (TIA) has been arbitrarily defined as a focal cerebral ischemic deficit lasting less than 24 hours.

Objective  To determine if TIAs of short duration (<1 hour) and long duration (1 hour to <24 hours) differ from each other and from ischemic stroke (IS).

Design, Setting, and Patients  Inception cohorts of 1429 patients with acute TIAs and 5206 patients with IS were prospectively documented in 15 German medical centers with neurology departments and acute stroke units. Outcome after 3 months was assessed in 72.8% of the patients with TIAs.

Main Outcome Measures  Risk factor distribution, etiology, and prognosis of TIAs and IS.

Results  Patients with TIAs, especially those with symptoms lasting less than 1 hour, were significantly more likely to have a history of TIAs and less likely to have diabetes mellitus, arterial hypertension, or atrial fibrillation at admission compared with those with IS. Cardioembolic etiologies were less frequent and unknown etiologies more frequent among patients with TIAs than those with IS. Functional outcome and mortality did not differ significantly in patients with TIAs of different durations.

Conclusion  This study demonstrates differences in comorbidity and etiology among patients with TIAs of different durations and IS.

From the Departments of Neurology, University of Essen, Essen (Drs Weimar, Kraywinkel, and Diener), Klinikum Nürnberg Süd, Nuremberg (Dr Rödl), University of Greifswald, Greifswald (Dr Hippe); University Charité Berlin, Berlin (Dr Harms), and University of Rostock, Rostock (Dr Kloth), Germany.

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