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Montse Alegret, PhD; Carme Junqué, PhD; Francesc Valldeoriola, MD; Pere Vendrell, PhD; Manuela Pilleri, MD; Jordi Rumià, MD; Eduardo Tolosa, MD

Arch Neurol. 2001;58:1223-1227.

Background  Chronic bilateral subthalamic deep brain stimulation (STN-DBS) is known to improve motor function in patients with Parkinson disease (PD). However, the possible effects of STN-DBS on neuropsychological functions have been studied less.

Objective  To investigate the effects of STN-DBS on neuropsychological functions in PD.

Design  Before-after trial.

Patients and Methods  Fifteen consecutive patients were assessed before and 3 months after implantation of stimulators for STN-DBS (postsurgical assessment with the stimulators switched on). Both assessments were performed with patients in a drug-free condition. The neuropsychological battery consisted of tests measuring memory and visuospatial and frontal functions.

Results  The comparison between presurgical and postsurgical performance showed a moderate deterioration in verbal memory and prefrontal and visuospatial functions, and a moderate improvement in a prefrontal task and obsessive-compulsive traits. The motor state improved in all patients.

Conclusion  Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration.

From the Department of Psychiatry and Clinical Psychobiology (Drs Alegret, Junqué, and Vendrell) and the Unit of Parkinson's and Movement Disorders (Drs Valldeoriola, Pilleri, and Tolosa), Service of Neurosurgery (Dr Rumià), Institut Clinic de Malalties del Sistema Nerviós, Department of Medicine, Hospital Clinic Universitari, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

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