 |
|
Effects of Bilateral Subthalamic Stimulation on Cognitive Function in Parkinson Disease
Montse Alegret, PhD;
Carme Junqué, PhD;
Francesc Valldeoriola, MD;
Pere Vendrell, PhD;
Manuela Pilleri, MD;
Jordi Rumià, MD;
Eduardo Tolosa, MD
Arch Neurol. 2001;58:1223-1227.
Background Chronic bilateral subthalamic deep brain stimulation (STN-DBS) is known to improve motor function in patients with Parkinson disease (PD). However, the possible effects of STN-DBS on neuropsychological functions have been studied less.
Objective To investigate the effects of STN-DBS on neuropsychological functions in PD.
Design Before-after trial.
Patients and Methods Fifteen consecutive patients were assessed before and 3 months after implantation of stimulators for STN-DBS (postsurgical assessment with the stimulators switched on). Both assessments were performed with patients in a drug-free condition. The neuropsychological battery consisted of tests measuring memory and visuospatial and frontal functions.
Results The comparison between presurgical and postsurgical performance showed a moderate deterioration in verbal memory and prefrontal and visuospatial functions, and a moderate improvement in a prefrontal task and obsessive-compulsive traits. The motor state improved in all patients.
Conclusion Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration.
From the Department of Psychiatry and Clinical Psychobiology (Drs Alegret, Junqué, and Vendrell) and the Unit of Parkinson's and Movement Disorders (Drs Valldeoriola, Pilleri, and Tolosa), Service of Neurosurgery (Dr Rumià), Institut Clinic de Malalties del Sistema Nerviós, Department of Medicine, Hospital Clinic Universitari, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
RELATED ARTICLES
Subthalamic Deep Brain Stimulation: Neurobehavioral Concerns
Gage Van Horn, Mya C. Schiess, and Vicki M. Soukup
Arch Neurol. 2001;58(8):1205-1206.
EXTRACT
| FULL TEXT
Archives of Neurology Reader's Choice: Continuing Medical Education
Arch Neurol. 2001;58(8):1319-1321.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson Disease: A Randomized Controlled Trial
Weaver et al.
JAMA 2009;301:63-73.
ABSTRACT
| FULL TEXT
Subthalamic Nucleus Stimulation in Severe Obsessive-Compulsive Disorder
Mallet et al.
NEJM 2008;359:2121-2134.
ABSTRACT
| FULL TEXT
Semantic and affective priming as a function of stimulation of the subthalamic nucleus in Parkinson's disease
Castner et al.
Brain 2007;130:1395-1407.
ABSTRACT
| FULL TEXT
Cognitive outcome 5 years after bilateral chronic stimulation of subthalamic nucleus in patients with Parkinson's disease
Contarino et al.
J. Neurol. Neurosurg. Psychiatry 2007;78:248-252.
ABSTRACT
| FULL TEXT
Neuropsychological effects of bilateral STN stimulation in Parkinson disease: A controlled study
Smeding et al.
Neurology 2006;66:1830-1836.
ABSTRACT
| FULL TEXT
Cognitive changes in Parkinson's disease during subthalamic stimulation: a clinicopathologic study
Valldeoriola et al.
J. Neurol. Neurosurg. Psychiatry 2006;77:565-566.
FULL TEXT
Sexual well being in parkinsonian patients after deep brain stimulation of the subthalamic nucleus
Castelli et al.
J. Neurol. Neurosurg. Psychiatry 2004;75:1260-1264.
ABSTRACT
| FULL TEXT
Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
Francois et al.
Brain 2004;127:2055-2070.
ABSTRACT
| FULL TEXT
Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease
Funkiewiez et al.
J. Neurol. Neurosurg. Psychiatry 2004;75:834-839.
ABSTRACT
| FULL TEXT
Defining a role for the subthalamic nucleus within operative theoretical models of subcortical participation in language
Whelan et al.
J. Neurol. Neurosurg. Psychiatry 2003;74:1543-1550.
ABSTRACT
| FULL TEXT
Deep Brain Stimulation of the Subthalamic Nucleus Enhances Emotional Processing in Parkinson Disease
Schneider et al.
Arch Gen Psychiatry 2003;60:296-302.
ABSTRACT
| FULL TEXT
Effects of High-Frequency Stimulation in the Internal Globus Pallidus on the Activity of Thalamic Neurons in the Awake Monkey
Anderson et al.
J. Neurophysiol. 2003;89:1150-1160.
ABSTRACT
| FULL TEXT
Cognitive and behavioural effects of chronic stimulation of the subthalamic nucleus in patients with Parkinson's disease
Daniele et al.
J. Neurol. Neurosurg. Psychiatry 2003;74:175-182.
ABSTRACT
| FULL TEXT
Subthalamic Deep Brain Stimulation: Neurobehavioral Concerns
Van Horn et al.
Arch Neurol 2001;58:1205-1206.
FULL TEXT
|
