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Current Concepts and Future Directions

Scott A. Small, MD

Arch Neurol. 2001;58:360-364.

The effect of age on memory and the brain has been the focus of many studies. Results have identified critical questions that need to be addressed to further our understanding of age-related memory decline: Is cognitive decline diffuse or selective? Where does memory decline localize to anatomically? Does decline represent an abnormal state? What are the causes of memory decline? What level of analysis is needed to investigate age-related cortical changes? These questions are reviewed herein, and attempts at early answers are discussed.

From the Division of Neurobehavior of the Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY.

Reprints: Scott A. Small, MD, Columbia University College of Physicians and Surgeons, 630 W 168 St, PH #19, New York, NY 10032.

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