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Sequence Analysis of the Human Genome
Implications for the Understanding of Nervous System Function and Disease
Anibal Cravchik, MD, PhD;
G. Subramanian, MD, PhD;
Samuel Broder, MD;
J. Craig Venter, PhD
Arch Neurol. 2001;58:1772-1778.
The recent publication of the
sequence of the human genome will accelerate the discovery of new
genetic susceptibility factors for human disease, leading to the
development of novel diagnostics and therapeutics. The exhaustive
analysis of the human genome sequence will be the focus of the
biomedical research community for many years to come. In particular,
comparative analysis of the available eukaryotic genome sequences is an
important approach to further our understanding of gene structure,
function, and evolution. Our initial analysis of the human genome
sequence has revealed many interesting features that are relevant to
nervous system function, evolution, and disease. We analyzed the
prominent features of predicted human proteins involved in neuronal
function and prepared a comparative analysis of 146 human genes that
have alleles (or mutations) conferring susceptibility for 168
neurologic diseases.
From Celera Genomics, Rockville, Md.
Corresponding author and reprints: Anibal Cravchik, MD,
PhD, Celera Genomics, 45 W Gude Dr, Rockville, MD 20850 (e-mail: Anibal.Cravchik{at}celera.com).
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