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Treatment of Ballism and Pseudobulbar Affect With Sertraline
Michael S. Okun, MD;
Alonso R. Riestra, MD;
Stephen E. Nadeau, MD
Arch Neurol. 2001;58:1682-1684.
Background The pathogenesis of ballism is uncertain and may involve more than one
mechanism; treatment is not always efficacious.
Objective To provide evidence of a nondopaminergic mechanism and the potential
for a prompt and nearly complete response to a serotonergic agent.
Methods Report of 2 separate trials of sertraline hydrochloride in a single
patient.
Results Complete remission of symptoms within 48 hours of each drug trial.
Conclusion Sertraline may offer an alternative with a better adverse effect profile
than dopamine receptor blockers in the treatment of patients with ballism.
From the Department of Neurology, Emory University (Dr Okun), Atlanta,
Ga; the Department of Neurology, University of Florida College of Medicine
(Drs Riestra and Nadeau), and the Geriatric Research, Education and Clinical
Center and the Brain Rehabilitation Research Center, Malcom Randall Department
of Veterans Affairs Medical Center (Dr Nadeau), Gainesville, Fla.
Corresponding author: Stephen E. Nadeau, MD, GRECC-182, Malcom Randall
DVA Medical Center, Gainesville, FL 32608-1197 (e-mail: snadeau{at}ufl.edu).
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