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Hereditary Neuropathy With Liability to Pressure Palsies Is Not a Major Cause of Idiopathic Carpal Tunnel Syndrome
David W. Stockton, MD;
Ricardo A. Meade, MD;
David T. Netscher, MD;
Michael J. Epstein, MD;
Saleh M. Shenaq, MD;
Lisa G. Shaffer, PhD;
James R. Lupski, MD, PhD
Arch Neurol. 2001;58:1635-1637.
Background Carpal tunnel syndrome is a debilitating neuropathy affecting millions
of individuals. Although there are published reports of familial associations
of carpal tunnel syndrome, the molecular mechanisms are unknown.
Objective To determine the prevalence and potential role of the chromosome 17
microdeletion associated with hereditary neuropathy with liability to pressure
palsies in patients diagnosed as having carpal tunnel syndrome.
Design Prospective study.
Patients and Methods Since hereditary neuropathy with liability to pressure palsies may present
as carpal tunnel syndrome, we evaluated 50 patients with idiopathic carpal
tunnel syndrome for hereditary neuropathy with liability to pressure palsies.
Results No hereditary neuropathy with liability to pressure palsies deletions
were detected.
Conclusion Molecular genetic testing for hereditary neuropathy with liability to
pressure palsies in patients with idiopathic carpal tunnel syndrome is of
limited value.
From the Departments of Molecular and Human Genetics (Drs Stockton,
Shaffer, and Lupski), Medicine (Dr Stockton), Ophthalmology (Dr Stockton),
and Pediatrics (Dr Lupski) and the Division of Plastic Surgery (Drs Meade,
Netscher, Epstein, and Shenaq), Baylor College of Medicine, Houston, Tex,
and the Division of Plastic Surgery Veterans Affairs Medical Center, Houston
(Dr Netscher).
Reprints: David W. Stockton, MD, One Baylor Plaza, Room 604B, Houston,
TX 77030 (e-mail: stockton{at}bcm.tmc.edu).
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