 |
|
Extent of Cerebral White Matter Lesions Is Related to Changes of Circadian Blood Pressure Rhythmicity
Dirk Sander, MD;
Kerstin Winbeck, MD;
Jürgen Klingelhöfer, MD;
Bastian Conrad, MD
Arch Neurol. 2000;57:1302-1307.
Objective To evaluate the relationship between circadian blood pressure patterns and the extent of cerebral white matter lesions (WML).
Design Case-control study.
Participants A total of 227 healthy subjects older than 55 years were investigated. Extent and occurrence of WML were evaluated using a computer-supported image analysis system. Circadian blood pressure variation was defined as the average percentage change of nighttime blood pressure compared with the daily blood pressure values.
Results Subjects with WML were significantly older and showed more often a history of hypertension, elevated average systolic daily blood pressure, a reduced systolic circadian blood pressure variation, and an increased incidence of pathological nighttime blood pressure increases. A significant correlation was found between systolic circadian blood pressure variation and the extent of WML. A multiple regression analysis revealed that this parameter was best correlated with the extent of WML.
Conclusion In addition to the absolute level of blood pressure, systolic circadian blood pressure variation and in particular a systolic nighttime blood pressure increase may play an important role in the pathogenesis of WML.
From the Department of Neurology, Technical University of Munich (Drs Sander, Winbeck, and Conrad) and Klinikum Chemnitz (Dr Klingelhöfer), Munich, Germany.
RELATED ARTICLE
Archives of Neurology Reader's Choice: Continuing Medical Education
Arch Neurol. 2000;57(9):1387-1388.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Association of Blood Pressure and Genetic Background With White Matter Lesions in Patients With Mild Cognitive Impairment
Galluzzi et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2008;63:510-517.
ABSTRACT
| FULL TEXT
Association of Ambulatory Blood Pressure With Ischemic Brain Injury
Schwartz et al.
Hypertension 2007;49:1228-1234.
ABSTRACT
| FULL TEXT
Ambulatory blood pressure and the brain: A 5-year follow-up
Goldstein et al.
Neurology 2005;64:1846-1852.
ABSTRACT
| FULL TEXT
Plasma Homocysteine Levels, Cerebrovascular Risk Factors, and Cerebral White Matter Changes (Leukoaraiosis) in Patients With Alzheimer Disease
Hogervorst et al.
Arch Neurol 2002;59:787-793.
ABSTRACT
| FULL TEXT
Cerebral Perfusion and Cerebrovascular Reactivity Are Reduced in White Matter Hyperintensities
Marstrand et al.
Stroke 2002;33:972-976.
ABSTRACT
| FULL TEXT
Twenty-four-Hour Blood Pressure and MRI as Predictive Factors for Different Outcomes in Patients With Lacunar Infarct
Yamamoto et al.
Stroke 2002;33:297-305.
ABSTRACT
| FULL TEXT
|
