 |
|
Contribution of Lewy Body Inclusions to Dementia in Patients With and Without Alzheimer Disease Neuropathological Conditions
Vahram Haroutunian, PhD;
Michael Serby, MD;
Dushyant P. Purohit, MD;
Daniel P. Perl, MD;
Deborah Marin, MD;
Melinda Lantz, MD;
Richard C. Mohs, PhD;
Kenneth L. Davis, MD
Arch Neurol. 2000;57:1145-1150.
Context Lewy bodies (LBs) are intraneuronal inclusions in the brain that have been increasingly recognized as neuropathological lesions with relevance not only to Parkinson disease but also to Alzheimer disease. However, the degree to which the density of LBs in the brain contributes to the severity of dementia has not been clear.
Objective To determine the degree to which LB "burden" contributes to dementia.
Design Brain specimens were examined from 273 consecutive autopsies of elderly subjects residing in a nursing home. The numbers and densities of LBs were determined in multiple brain regions, and their correlation with a measure of cognition and functional status (Clinical Dementia Rating) during the 6 months preceding death was determined.
Setting and Patients Postmortem study of nursing home residents.
Results The severity of dementia correlated significantly and positively with the density of LBs. These correlations were independent of other neuropathological disorders commonly associated with dementia, including Alzheimer disease. The density of LBs correlated significantly with dementia severity whether or not the diagnostic criteria for Alzheimer disease were met and after the contribution of classical Alzheimer disease lesions, neuritic plaques, and neurofibrillary tangles had been accounted for by partial correlation analysis.
Conclusion Lewy body inclusions appear to contribute significantly to cognitive deficits in the elderly in a manner that is independent of other neuropathological disorders.
From the Departments of Psychiatry (Drs Haroutunian, Serby, Marin, Mohs, and Davis) and Pathology (Drs Purohit and Perl), The Mount Sinai School of Medicine, New York, NY; Psychiatry Service, Bronx Veterans Affairs Medical Center, Bronx, NY (Drs Haroutunian, Serby, Marin, Mohs, and Davis) and Jewish Home and Hospital, New York (Dr Lantz).
RELATED ARTICLE
Archives of Neurology Reader's Choice: Continuing Medical Education
Arch Neurol. 2000;57(8):1241-1242.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Patterns and stages of {alpha}-synucleinopathy: Relevance in a population-based cohort
Zaccai et al.
Neurology 2008;70:1042-1048.
ABSTRACT
| FULL TEXT
Imaging {beta}-amyloid burden in aging and dementia
Rowe et al.
Neurology 2007;68:1718-1725.
ABSTRACT
| FULL TEXT
Clinical phenotype of Parkinson disease dementia.
Galvin et al.
Neurology 2006;67:1605-1611.
ABSTRACT
| FULL TEXT
Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
Beeri et al.
Neurology 2006;66:1399-1404.
ABSTRACT
| FULL TEXT
Relation of Quantitative Indexes of Concurrent {alpha}-Synuclein Abnormalities to Clinical Outcome in Autopsy-Proven Alzheimer Disease
Holtzer et al.
Arch Neurol 2006;63:226-230.
ABSTRACT
| FULL TEXT
Increased Hippocampal Plaques and Tangles in Patients With Alzheimer Disease With a Lifetime History of Major Depression
Rapp et al.
Arch Gen Psychiatry 2006;63:161-167.
ABSTRACT
| FULL TEXT
The E46K Mutation in {alpha}-Synuclein Increases Amyloid Fibril Formation
Greenbaum et al.
J. Biol. Chem. 2005;280:7800-7807.
ABSTRACT
| FULL TEXT
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease
Tsuang et al.
Neurology 2005;64:509-513.
ABSTRACT
| FULL TEXT
Neuropathological Substrates of Psychiatric Symptoms in Prospectively Studied Patients With Autopsy-Confirmed Dementia With Lewy Bodies
Ballard et al.
Am. J. Psychiatry 2004;161:843-849.
ABSTRACT
| FULL TEXT
Can Alzheimer's Disease and Dementias with Lewy Bodies be Distinguished Clinically?
Weiner et al.
J Geriatr Psychiatry Neurol 2003;16:245-250.
ABSTRACT
Cognitive Burden and Excess Lewy-Body Pathology in the Lewy-Body Variant of Alzheimer Disease
Serby et al.
AJGP 2003;11:371-374.
ABSTRACT
| FULL TEXT
Dementia in Parkinson Disease: A Proton Magnetic Resonance Spectroscopy Study
Summerfield et al.
Arch Neurol 2002;59:1415-1420.
ABSTRACT
| FULL TEXT
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
Harding et al.
Brain 2002;125:391-403.
ABSTRACT
| FULL TEXT
Parkinson Disease Neuropathology: Later-Developing Dementia and Loss of the Levodopa Response
Apaydin et al.
Arch Neurol 2002;59:102-112.
ABSTRACT
| FULL TEXT
|
