 |
|
Left Frontotemporal Hypoperfusion Is Associated With Aggression in Patients With Dementia
Nobutsugu Hirono, MD;
Michael S. Mega, MD, PhD;
Ivo D. Dinov, PhD;
Fred Mishkin, MD;
Jeffrey L. Cummings, MD
Arch Neurol. 2000;57:861-866.
Background Aggressive behavior is common in patients with dementia. Temporolimbic and prefrontal cortical lesions can produce pathological aggression; however, involvement of these structures has not been established in aggressive patients with dementia.
Objective To study the relation between regional brain perfusion and aggressive behavior in patients with dementia.
Methods We compared the pattern of regional cerebral perfusion determined with technetium Tc 99m–labeled hexamethylpropelene amineoxime single photon emission computed tomography in 2 groups of 10 patients with dementia with and without aggression, that were comparable for demographic factors, severity of cognitive impairments, and other behavioral symptoms as measured by the Neuropsychiatric Inventory.
Results Patients with aggression revealed significant (P<.001) hypoperfusion in the left anterior temporal cortex; additional bilateral dorsofrontal and right parietal cortex were also found to be significantly hypoperfused.
Conclusion These results indicated an association between aggression and decreased perfusion in the left anterior temporal cortex.
From the Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan (Dr Hirono); Departments of Neurology (Drs Hirono, Mega, and Cummings) and Nuclear Medicine (Dr Mishkin), Harbor/UCLA Medical Center, Torrence; and the Laboratory of Neuroimaging (Drs Mega and Dinov) and Alzheimer's Disease Research Center (Drs Hirono, Mega, and Cummings), UCLA School of Medicine, Los Angeles, Calif.
RELATED ARTICLE
Archives of Neurology Reader's Choice: Continuing Medical Education
Arch Neurol. 2000;57(6):902-904.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Aggression in Individuals Newly Diagnosed With Dementia
Orengo et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2008;23:227-232.
ABSTRACT
The Influence of Neuropsychological Functioning on Neuropsychiatric Problems in Dementia
Aalten et al.
J. Neuropsychiatry Clin. Neurosi. 2007;19:50-56.
ABSTRACT
| FULL TEXT
Neuroimaging Studies of Aggressive and Violent Behavior: Current Findings and Implications for Criminology and Criminal Justice
Bufkin and Luttrell
Trauma Violence Abuse 2005;6:176-191.
ABSTRACT
Medial Temporal Hypoperfusion and Aggression in Alzheimer Disease
Lanctot et al.
Arch Neurol 2004;61:1731-1737.
ABSTRACT
| FULL TEXT
Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's disease
Craig et al.
J. Neurol. Neurosurg. Psychiatry 2004;75:1327-1330.
ABSTRACT
| FULL TEXT
Social Cognition and the Prefrontal Cortex
Wood
Behav Cogn Neurosci Rev 2003;2:97-114.
ABSTRACT
ADVANCES IN NEUROPSYCHIATRY: Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review
Brower and Price
J. Neurol. Neurosurg. Psychiatry 2001;71:720-726.
ABSTRACT
| FULL TEXT
|
