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Premorbid Reading Activity and Patterns of Cognitive Decline in Alzheimer Disease
Robert S. Wilson, PhD;
David A. Bennett, MD;
David W. Gilley, PhD;
Laurel A. Beckett, PhD;
Lisa L. Barnes, PhD;
Denis A. Evans, MD
Arch Neurol. 2000;57:1718-1723.
Background Educational and occupational attainment have been associated with progression of Alzheimer disease in some studies. One hypothesis about this association is that education and occupation are markers for lifelong participation in cognitively stimulating activities like reading.
Objective To assess the relation of premorbid reading activity with patterns of cognitive decline in Alzheimer disease.
Methods During a 4-year period, 410 persons with Alzheimer disease had annual clinical evaluations, which included administration of 17 cognitive function tests from which global, verbal, and nonverbal summary measures were derived. At baseline, a knowledgeable informant was questioned about the affected person's reading frequency and access to reading materials before dementia onset.
Results A composite measure of premorbid reading activity was developed. It had moderately high internal consistency and was positively correlated with education and baseline level of cognitive function. In analyses that controlled for baseline cognitive function, education, and other demographic variables, higher level of premorbid reading activity was associated with more rapid decline on the global cognitive and verbal measures but not on the nonverbal measure.
Conclusions These results suggest that both the extent and nature of premorbid cognitive experiences may affect how Alzheimer disease pathology is clinically expressed.
From the Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging, and Departments of Neurological Sciences (Drs Wilson, Bennett, Gilley, and Barnes), Medicine (Drs Beckett and Evans), and Psychology (Drs Wilson, Gilley, and Barnes), Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill.
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