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Incidence of Optic Neuritis in Stockholm, Sweden, 1990-1995
II. Time and Space Patterns
Ya-Ping Jin, MD;
Jesús de Pedro-Cuesta, MD, PhD;
Mats Söderström, MD, PhD;
Hans Link, MD, PhD
Arch Neurol. 1999;56:975-980.
Objectives To describe the time and space patterns of patients with monosymptomatic optic neuritis (MON) in Stockholm County, Sweden, and to explore the role of environmental factors in the etiology of MON and multiple sclerosis.
Design Population-based and prospective incidence survey.
Setting Census based on referrals from 1.68 million inhabitants of Stockholm County.
Patients One hundred forty-seven new patients with MON were consecutively referred by ophthalmologists and neurologists from January 1, 1990, through December 31, 1995. A standardized questionnaire was used for data collection.
Main Outcome Measures Evaluations consisted of annual incidence, statistical significance of temporal aggregation, Knox test, likelihood score test applied to the ratio of the highest to lowest seasonal proportion of registered events, and standardized morbidity ratio for municipalities.
Results We observed a seasonal pattern of MON incidence, with the highest incidence (31%) in the spring and the lowest (17%) in the winter (ratio of highest to lowest seasonal proportion, 1.84; 95% confidence interval, 1.13-3.01; P=.007). The seasonal monthly incidences were correlated with the average number of sunny hours and the temperature. The presence of positive immune activity markers (ie, mononuclear pleocytosis and oligoclonal IgG bands in the cerebrospinal fluid) seemed to be linked to the onset of MON in winter. No aggregation by time, space, or month of birth was detected.
Conclusions Monosymptomatic optic neuritis in Stockholm County occurred at an uneven frequency across the seasons, with the highest incidence in spring and the lowest in winter. This seasonal pattern is compatible with that described in most previous reports. Environmental and probable infectious factors unevenly distributed by season may play a role in the etiology and early clinical course of MON.
From the Divisions of Neurology (Drs Jin, de Pedro-Cuesta, and Link) and Ophthalmology (Dr Söderström), Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden; the Division of Medical Statistics, Chongqing University of Medical Sciences, Chongqing, China (Dr Jin); and the Department of Applied Epidemiology, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain (Dr de Pedro-Cuesta).
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