Genetic Linkage Analysis
Stefan M. Pulst, MD
Arch Neurol. 1999;56:667-672.
Genetic linkage analysis is a powerful tool to detect the chromosomal location of disease genes. It is based on the observation that genes that reside physically close on a chromosome remain linked during meiosis. For most neurologic diseases for which the underlying biochemical defect was not known, the identification of the chromosomal location of the disease gene was the first step in its eventual isolation. By now, genes that have been isolated in this way include examples from all types of neurologic diseases, from neurodegenerative diseases such as Alzheimer, Parkinson, or ataxias, to diseases of ion channels leading to periodic paralysis or hemiplegic migraine, to tumor syndromes such as neurofibromatosis types 1 and 2.
From the Division of Neurology and Rose Moss Laboratory for Parkinson's and Neurodegenerative Diseases, Cedars-Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles.
RELATED ARTICLE
Archives of Neurology Reader's Choice: Continuing Medical Education
Arch Neurol. 1999;56(6):762-764.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
The genetic basis of Parkinson's disease
Foltynie et al.
J. Neurol. Neurosurg. Psychiatry 2002;73:363-370.
ABSTRACT
| FULL TEXT
Neuropsychiatric Genetics: Misclassification in Linkage Studies of Phenotype-Genotype Research
Burd et al.
J Child Neurol 2001;16:499-504.
ABSTRACT
Analysis of mammalian central nervous system gene expression and function using bacterial artificial chromosome-mediated transgenesis
Heintz
Hum Mol Genet 2000;9:937-943.
ABSTRACT
| FULL TEXT
|
