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John Jacob, MRCP; Tamas Revesz, FRCPath; Maria Thom, MRCPath; Martin N. Rossor, MD

Arch Neurol. 1999;56:1289-1291.

Background  Pick disease is an uncommon cause of dementia in middle age, and young-onset cases have rarely been reported.

Setting  A specialist hospital.

Patient  Patient with onset of cognitive impairment at the age of 27 years whose cerebral biopsy specimen demonstrated Pick cells and tau-positive Pick bodies.

Conclusion  Pick disease should be considered in the differential diagnosis of dementia in young adults.

From the Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, England.

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