This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (27)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Cerebrovascular Disease  • Alert me on articles by topic  Social Bookmarking   What's this?

Francesco Federico, MD; Isabella Laura Simone, MD; Vincenzo Lucivero, MD; Paolo Giannini, MD; Giuseppe Laddomada, MD; Domenico Maria Mezzapesa, MD; Carla Tortorella, MD

Arch Neurol. 1998;55:489-494.

Objective  To determine the correlation between metabolite concentrations and clinical outcome during the acute or subacute phase of ischemic stroke by using single-voxel localized proton magnetic resonance spectroscopy (¹H-MRS).

Setting  A university hospital neurologic department.

Patients and Methods  Combined single-voxel ¹H-MRS and magnetic resonance imaging were performed on 26 patients with a recent ischemic stroke (on 8 patients during the first 24 hours after the stroke and on 18 during the first week). For all patients, the signals from N-acetylaspartate, choline-containing compounds, and creatine-phosphocreatine were compared with those on the contralateral side as peak area ratios. The data for ¹H-MRS were related to scores on the Scandinavian Stroke Scale and the Barthel Index at a 6-month clinical follow-up.

Results  The signals from N-acetylaspartate, choline-containing compounds, and creatine-phosphocreatine were significantly reduced in all infarcted areas (P<.001, P <.001, and P=.003, respectively, Wilcoxon signed rank test). A lactate signal was present in 19 patients. The statistical analysis showed a significant positive correlation between N-acetylaspartate signals and Scandinavian Stroke Scale scores and between reduction of N-acetylaspartate signals and Barthel Index scores (Spearman rank correlation test). Patients in whom lactate was present had Scandinavian Stroke Scale scores significantly lower than patients in the group without lactate (Mann-Whitney U test).

Conclusion  Single-voxel ¹H-MRS performed during the acute or subacute phase of ischemic stroke may provide prognostic information.

From I Clinica Neurologica, University of Bari, Bari, Italy.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

RELATED ARTICLE

Stroke 1998
Roger N. Rosenberg
Arch Neurol. 1998;55(4):448.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Changes in NAA and lactate following ischemic stroke: A serial MR spectroscopic imaging study
Munoz Maniega et al.
Neurology 2008;71:1993-1999.
ABSTRACT | FULL TEXT  

Prefrontal N-Acetylaspartate and Poststroke Recovery: A Longitudinal Proton Spectroscopy Study
Glodzik-Sobanska et al.
Am. J. Neuroradiol. 2007;28:470-474.
ABSTRACT | FULL TEXT  

Magnetic resonance imaging and spectroscopic changes in brains of patients with cerebrotendinous xanthomatosis
De Stefano et al.
Brain 2001;124:121-131.
ABSTRACT | FULL TEXT  

Magnetic Resonance Techniques for the Identification of Patients With Symptomatic Carotid Artery Occlusion at High Risk of Cerebral Ischemic Events
Klijn et al.
Stroke 2000;31:3001-3007.
ABSTRACT | FULL TEXT  

Combined 1H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome
Parsons et al.
Neurology 2000;55:498-506.
ABSTRACT | FULL TEXT  

Axonal Injury in the Internal Capsule Correlates With Motor Impairment After Stroke
Pendlebury et al.
Stroke 1999;30:956-962.
ABSTRACT | FULL TEXT  

Stroke 1998
Rosenberg
Arch Neurol 1998;55:448-448.
FULL TEXT