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The G209A Mutation in the -Synuclein Gene Is Not Detected in Familial Cases of Parkinson Disease in Non-Greek and/or Italian Populations

William W. Wang, MD, PhD; Mehrdad Khajavi, BS; Bhavna J. Patel, BS; Jennifer Beach, RN; Joseph Jankovic, MD; Tetsuo Ashizawa, MD

Arch Neurol. 1998;55:1521-1523.

Objective  To determine whether the G-to-A substitution at nucleotide 209 (G209A) mutation in the -synuclein gene is responsible for familial Parkinson disease (PD) in the US population.

Design  Polymerase chain reaction–based DNA analysis of consecutive patients with PD and family history of PD.

Setting  A university-affiliated movement disorder clinic and a Veterans Affairs clinical research laboratory.

Patients  Forty-four patients with PD and family history of PD and 29 patients with sporadic PD, all with no known Greek and/or Italian background.

Results  None of the DNA samples showed the G209A mutation.

Conclusion  The G209A mutation is rare in US patients with familial PD.

From the Veterans Affairs Medical Center (Drs Wang, Khajavi, Patel, and Ashizawa) and the Department of Neurology, Baylor College of Medicine (Drs Wang, Beach, Jankovic, and Ashizawa), Houston, Tex.

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