Role of Antiribosomal P Protein Antibodies in the Diagnosis of Lupus Isolated to the Central Nervous System
Mark A. Agius, MD;
Jane W. Chan, MD;
Stephen Chung, MD;
Eun-Kyu Lee, MD
Arch Neurol. 1997;54(7):862-864.
Abstract
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Background
When lupus presents with isolated central nervous system findings, the usual serologic markers are often absent and diagnostic difficulty with a delay in treatment is common.
Objective
To report the usefulness of antiribosomal P protein antibodies in the diagnosis of lupus isolated to the central nervous system when results of tests for anti—double-stranded DNA antibodies are negative.
Design
Case report.
Setting
University medical center.
Patient
The patient was evaluated and treated on referral and followed up for 1 year.
Results
We describe a patient with acute onset of psychosis followed by coma and focal clonic movements with undetectable DNA antibodies. Serum antiribosomal P protein antibody levels were elevated. Steroid therapy was followed by marked clinical improvement and a decrease in antibody titer.
Conclusion
Antiribosomal P protein antibodies provide an important confirmatory test for the diagnosis of lupus isolated to the central nervous system when results of tests for anti—double-stranded DNA antibodies are negative.
Author Affiliations
From the Department of Neurology, University of California, Davis.
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