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Rosemary Fama, PhD; Edith V. Sullivan, PhD; Paula K. Shear, PhD; Laura Marsh, MD; Jerome A. Yesavage, MD; Jared R. Tinklenberg, MD; Kelvin O. Lim, MD; Adolf Pfefferbaum, MD

Arch Neurol. 1997;54(6):719-728.

Abstract
Objective
To examine whether each of the 5 Mattis Dementia Rating Scale (DRS) scores related to magnetic resonance imaging—derived volumes of specific cortical or limbic brain regions in patients with Alzheimer disease (AD).

Design
Relations between DRS measures and regional brain volume measures were tested with bivariate and multivariate regression analyses.

Setting
The Aging Clinical Research Center of the Stanford (Calif) University Department of Psychiatry and Behavioral Science and the Geriatric Psychiatry Rehabilitation Unit of the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.

Patients and Other Participants
Fifty patients with possible or probable AD. Magnetic resonance imaging data from 136 healthy control participants, age 20 to 84 years, were used to correct brain volumes for normal variation arising from intracranial volume and age.

Main Outcome Measures
The DRS scores and volumes of regional cortical gray matter and of the hippocampus.

Results
Memory scores of the patients with AD were selectively related to hippocampal volumes. Attention and construction scores were related to several anterior brain volume measures, with attention showing a significantly greater association to right than left hemisphere measures. Initiation/perseveration scores were not significantly correlated with any measure of regional gray matter volume, but performance was related to prefrontal sulcal widening, with a greater association with the left than right sulcal volume.

Conclusions
Certain DRS subtests are predictably correlated with selective regional brain volumes in AD. The specific relation between memory and hippocampal volumes and the nonsignificant relations between memory and regional cortical volumes suggest a dissociation between cortical and hippocampal contributions to explicit memory performance.

Author Affiliations
From the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif (Drs Fama, Sullivan, Shear, Marsh, Yesavage, Tinklenberg, Lim, and Pfefferbaum); the Psychiatry Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif (Drs Yesavage, Tinklenberg, and Lim); and the Neuropsychiatry Program, SRI International, Menlo Park, Calif (Drs Sullivan and Pfefferbaum). Dr Shear is now in the Department of Psychology, University of Cincinnati, Cincinnati, Ohio.

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