Progressive Deterioration of Intellect and Motor Function Occurring Several Decades After Cranial IrradiationA New Facet in the Clinical Spectrum of Radiation Encephalopathy
Philip Duffey, MB, MRCP;
Ganesh Chari, MB, MRCP;
Niall E. F. Cartlidge, FRCP;
Pamela J. Shaw, MD, FRCP
Arch Neurol. 1996;53(8):814-818.
Abstract
Objective
To report the cases of 2 patients who developed the features of radiation encephalopathy 33 and 28 years after cranial irradiation.
Design
Case reports; clinical data were available for 2 years in each instance.
Conclusion
Latent intervals approaching 2 decades have been reported in cases of radiation necrosis following cranial irradiation, but a similar or greater delay before the onset of radiation encephalopathy has not been described previously. This report indicates that a diagnosis of radiation encephalopathy must be considered when any individual who has received cranial irradiation presents with deterioration in intellectual or motor function, whatever the interval.
Author Affiliations
From the Department of Neurology, Royal Victoria Infirmary, Newcastle Upon Tyne, England.
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