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V. Jane Kattapong, MD; William M. Brooks, PhD; Mary H. Wesley; Piyadasa W. Kodituwakku, PhD; Gary A. Rosenberg, MD

Arch Neurol. 1996;53(7):678-680.

Abstract
Objective
To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia.

Design and Subjects
Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia.

Results
The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P<.02).

Conclusion
Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.

Author Affiliations
From the Departments of Neurology (Drs Kattapong and Rosenberg and Ms Wesley) and Psychiatry (Dr Kodituwakku) and Center for Non-Invasive Diagnosis (Dr Brooks), University of New Mexico School of Medicine, and the Neurology Service, Veterans Affairs Medical Center, Albuquerque, NM. Dr Kattapong is currently with the Department of Neurology, University of Vermont College of Medicine, Burlington.

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