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The Role of Magnetic Resonance Imaging in the Diagnosis of Alzheimer Disease in Adults With Down Syndrome
V. P. Prasher, MMedSc, MRCPsych, MD;
P. C. Barber, MRCPath;
R. West, MRCP;
Pat Glenholmes, RMNS
Arch Neurol. 1996;53(12):1310-1313.
Abstract
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Objective
To correlate findings from magnetic resonance imaging (MRI) with neuropathological analysis and clinical assessment of Alzheimer disease in patients with Down syndrome.
Design and Methods
Case study of 1 elderly man with trisomy 21 and Alzheimer disease who had been followed up prospectively over a 5-year period. The patient was a resident in a supervised community unit and died with end-stage dementia. The MRI changes were correlated with the results of clinical psychopathological analysis and neuropathological brain tissue findings. To our knowledge, this is the first case in which clinical, MRI, and neuropathological data were available in a case involving an elderly patient with Down syndrome and Alzheimer disease.
Results
The MRI findings correlated with the clinical deterioration and neuropathological features of Alzheimer disease. Marked changes in temporal and hippocampal regions were found.
Conclusion
Magnetic resonance imaging is potentially a valuable tool in the diagnosis of Alzheimer disease in adults with Down syndrome, particularly in individuals for whom standard intellectual assessments are not possible.
Author Affiliations
From the Departments of Psychiatry (Dr Prasher) and Pathology (Dr Barber), University of Birmingham, the Department of Radiology, Queen Elizabeth Hospital (Dr West), and Monyhull Hospital (Ms Glenholmes), Birmingham, England.
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