 |
|
Abnormal Pattern of Platelet APP Isoforms in Alzheimer Disease and Down Syndrome
Monica Di Luca, PhD;
Lucia Pastorino, PhD;
Flaminio Cattabeni, PhD;
Raffaella Zanardi, MD;
Silvio Scarone, MD;
Giorgio Racagni, PhD;
Enrico Smeraldi, MD;
Jorge Perez, MD, PhD
Arch Neurol. 1996;53(11):1162-1166.
Abstract
| |
Objective
To determine if changes in levels of amyloid precursor protein (APP) isoforms in periphery are associated with Alzheimer disease and Down syndrome.
Design
After subjects were grouped according to diagnosis, APP isoform levels in platelets were compared.
Setting
University medical center.
Subjects
Ten patients who fulfilled diagnostic criteria for probable Alzheimer disease, 22 healthy volunteers, and 7 elderly (mean age, 42.7 years) and 7 young (mean age, 19.0 years) patients with Down syndrome.
Main Outcome Measures
The levels of APP isoforms were evaluated by means of Western blot analysis and immunostaining of whole platelets.
Results
The ratio between the 130- and the 106- to 110-kd APP isoforms was markedly lower in patients with Alzheimer disease and in elderly patients with Down syndrome than in control subjects. In young patients with Down syndrome, the ratio did not significantly differ from that in control subjects.
Conclusions
A consistent alteration in platelet APP isoforms has been found in Alzheimer disease and Down syndrome. Further studies will determine whether this alteration could provide a peripheral biochemical marker of the disorder and whether it could intervene in the pathogenesis of Alzheimer disease.
Author Affiliations
From the Institute of Pharmacological Sciences, School of Pharmacy (Drs Di Luca, Pastorino, Cattabeni, Racagni, and Perez), and the Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine (Drs Zanardi, Scarone, Smeraldi, and Perez), the University of Milano, Milan, Italy.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Abnormalities in the Pattern of Platelet Amyloid Precursor Protein Forms in Patients With Mild Cognitive Impairment and Alzheimer Disease
Padovani et al.
Arch Neurol 2002;59:71-75.
ABSTRACT
| FULL TEXT
Amyloid precursor protein in platelets: A peripheral marker for the diagnosis of sporadic AD
Padovani et al.
Neurology 2001;57:2243-2248.
ABSTRACT
| FULL TEXT
Amyloid Precursor Protein in Platelets of Patients With Alzheimer Disease: Effect of Acetylcholinesterase Inhibitor Treatment
Borroni et al.
Arch Neurol 2001;58:442-446.
ABSTRACT
| FULL TEXT
The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg lecture
Rosenberg
Neurology 2000;54:2045-2054.
FULL TEXT
Platelet APP isoform ratios correlate with declining cognition in AD
Baskin et al.
Neurology 2000;54:1907-1909.
ABSTRACT
| FULL TEXT
Abnormalities of Amyloid {beta} Precursor Protein Expression in Platelets of Patients With Alzheimer Disease: Do We Understand Them Well Enough?
Blasko et al.
Arch Neurol 1999;56:889-891.
FULL TEXT
Products of the Alzheimer's disease amyloid precursor protein generated by,{beta}-secretase are present in human platelets, and secreted upon degranulation
Li et al.
AM J ALZHEIMERS DIS OTHER DEMEN 1998;13:236-244.
ABSTRACT
Alzheimer Disease-Related Abnormalities of Amyloid {beta} Precursor Protein Isoforms in the Platelet: The Brain's Delegate in the Periphery?
Bush and Tanzi
Arch Neurol 1998;55:1179-1180.
FULL TEXT
Differential Level of Platelet Amyloid {beta} Precursor Protein Isoforms: An Early Marker for Alzheimer Disease
Di Luca et al.
Arch Neurol 1998;55:1195-1200.
ABSTRACT
| FULL TEXT
Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease
Gasparini et al.
FASEB J. 1998;12:17-34.
ABSTRACT
| FULL TEXT
Altered Amyloid Protein Processing in Platelets of Patients With Alzheimer Disease
Rosenberg et al.
Arch Neurol 1997;54:139-144.
ABSTRACT
|
