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Magnetic Resonance Imaging and High-Resolution Positron Emission Tomography Demonstrate Functional Left-Right Asymmetry

Hans Karbe, MD; Michael Würker, MD; Karl Herholz, MD; Morad Ghaemi, MD; Uwe Pietrzyk, PhD; Josef Kessler, PhD; Wolf-Dieter Heiss, MD

Arch Neurol. 1995;52(9):869-874.

Abstract
Objective
To describe the registered analysis of magnetic resonance imaging and glucose metabolic data acquired with positron emission tomography to determine the relationship between structure and function of temporal lobe cortical structures between the left and right hemispheres.

Background
The dominance of the left cerebral hemisphere is associated with a preponderance of the left planum temporale.

Subjects and Methods
Fifteen subjects without signs or symptoms of a neurological disorder. Three-dimensional-registered magnetic resonance imaging and positron emission tomography with the use of fludeoxyglucose F18 and a high-resolution positron emission tomography scanner. Analysis of regional metabolic activation during single-word repetition on matched parasagittal magnetic resonance imaging and positron emission tomography.

Results
The planum temporale was bilaterally activated without left-right asymmetry. The metabolic increase was asymmetric within the left Brodmann's area (BA) 22. The part of the left BA 22 that was buried in the superior temporal sulcus was significantly less activated than the part of BA 22 on the surface of the superior temporal gyrus. The metabolic activation in the sulcal part of the left BA 22 had a significant inverse correlation with the anatomical predominance of the left planum temporale (r=.71, P=.003) and a significant direct correlation with the metabolic activation in the surface aspects of the right BA 22 (r=.82, P<.001).

Conclusion
Brodmann's area 22 is a critical feature of language dominance and is also important with regard to the exchange of information between the two hemispheres.

Author Affiliations
From the Department of Neurology, University Hospital (Drs Karbe, Würker, Herholz, Pietrzyk, and Heiss), and the Max-Planck-Institute of Neurological Research (Drs Ghaemi, Kessler, and Heiss), Cologne, Germany.

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