Intraoperative hippocampal cooling and Wada memory testing in the evaluation of amnesia risk following anterior temporal lobectomy
G. P. Lee, D. W. Loring, J. R. Smith and H. F. Flanigin
Department of Surgery (Neurosurgery), Medical College of Georgia, Augusta, USA.
OBJECTIVE: To determine the efficacy of memory testing following localized
thermal inactivation (cooling) of the hippocampus during epilepsy surgery
to assess risk for postoperative memory decline. DESIGN: Memory was
assessed after intraoperative thermal inactivation of the hippocampus and
during the Wada procedure to help determine the clinical utility of each
procedure. SETTING: A university hospital, comprehensive epilepsy surgery
program. PATIENTS: Individuals undergoing unilateral temporal lobectomy for
relief of intractable seizures. PROCEDURE: After temporal tip resection,
iced liquid was irrigated into the temporal horn of the lateral ventricle
until the hippocampus was "cooled." MAIN OUTCOME MEASURES: Multiple
neuropsychological measures of learning and memory. RESULTS: Wada memory
testing suggested risk for memory impairment in 15 patients while cooling
indicated risk in only five patients. Predictions arising from the two
procedures were concordant in 13 patients and discordant in 12 patients.
Among the 12 inconsistent predictions, hippocampal cooling suggested
adequate contralateral memory support in 11 (92%) of 12 patients, and none
of these 11 patients had a postoperative anterograde amnesia. CONCLUSION:
Intraoperative hippocampal cooling may be useful in determining the risk of
postoperative memory disorder among selected patients undergoing epilepsy
surgery.