This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Nicola Wolfe, PhD; Bruce R. Reed, PhD; Jamie L. Eberling, PhD; William J. Jagust, MD

Arch Neurol. 1995;52(3):257-262.

Abstract
Objective
To examine the ability of relative regional cerebral blood flow as measured by single photon emission computed tomography to predict longitudinal course of cognitive decline in Alzheimer's disease.

Design
Single photon emission computed tomography using the blood flow tracer ¹²³I-N-isopropyl-p-iodoamphetamine was performed at initial evaluation and was used to predict the rate of cognitive decline over a follow-up period from 1 to 4 years.

Setting
Outpatient university dementia clinic and center for functional imaging.

Participants
Twenty-nine patients met National Institute of Neurological and Communicative Disorders and Stroke—Alzheimer's Disease and Related Disorders Association criteria for probable or possible AD.

Results
Temporal lobe regional cerebral blood flow ratio at initial evaluation correlated with rate of decline in Mini-Mental State Examination over the longitudinal follow-up. Temporal regional cerebral blood flow ratio also predicted rate of decline of specific memory measures on the California Verbal Learning Test. Neither parietal nor frontal ratios predicted rate of cognitive decline. Dorsolateral frontal hypoperfusion was associated with the emergence of perseverative behaviors over time. Age, prior dementia duration, estimated prior rate of decline, and initial severity did not predict rate of cognitive decline.

Conclusion
Results suggest that regional perfusion on single photon emission computed tomography may predict cognitive decline in Alzheimer's disease better than these demographic and course variables.

Author Affiliations
From the University of California—Davis—Northern California Alzheimer's Disease Center, Department of Neurology, University of California—Davis, and Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California—Berkeley.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Critical Review of Memory Stimulation Programs in Alzheimer's Disease
Grandmaison and Simard
J. Neuropsychiatry Clin. Neurosi. 2003;15:130-144.
ABSTRACT | FULL TEXT  

Diffusion and Perfusion MR Imaging in Cases of Alzheimer's Disease: Correlations with Cortical Atrophy and Lesion Load
Bozzao et al.
Am. J. Neuroradiol. 2001;22:1030-1036.
ABSTRACT | FULL TEXT  

Frontal Lobe Hypometabolism Predicts Cognitive Decline in Patients With Lacunar Infarcts
Reed et al.
Arch Neurol 2001;58:493-497.
ABSTRACT | FULL TEXT  

Change in Cognitive Function in Older Persons From a Community Population: Relation to Age and Alzheimer Disease
Wilson et al.
Arch Neurol 1999;56:1274-1279.
ABSTRACT | FULL TEXT  

Temporal lobe abnormalities in dementia and depression: a study using high resolution single photon emission tomography and magnetic resonance imaging
Ebmeier et al.
J. Neurol. Neurosurg. Psychiatry 1997;63:597-604.
ABSTRACT | FULL TEXT  

Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer's disease
Grossman et al.
J. Neurol. Neurosurg. Psychiatry 1997;63:152-158.
ABSTRACT | FULL TEXT  

Age at Onset and Pattern of Neuropsychological Impairment in Mild Early-Stage Alzheimer Disease: A Study of a Community-Based Population
Reid et al.
Arch Neurol 1996;53:1056-1061.
ABSTRACT