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A Population-Based Case-Control Study

Pei Shan Wang, MD; W. T. Longstreth, Jr, MD; Thomas D. Koepsell, MD

Arch Neurol. 1995;52(2):202-204.

Abstract
Objective
To evaluate family history as a risk factor for subarachnoid hemorrhage.

Design and Setting
A population-based case-control study in King County, Washington.

Subjects
Cases consisted of 149 patients with spontaneous subarachnoid hemorrhage. Two control subjects who were matched to cases by gender and age within 5 years were identified for each case using random digit telephone dialing.

Main Measure
Detailed information on family history was obtained through an in-person interview.

Results
Some 11.4% of cases had a first-degree relative with a history of subarachnoid hemorrhage, compared with 6.4% of controls, yielding an odds ratio of 1.8 (95% CI, 0.92 to 3.7). The odds ratio for a positive family history among other relatives was 2.4 (95% CI, 1.1 to 5.2), likely reflecting family information bias. Findings were similar after adjustment was made for potential confounding variables, including cigarette smoking, a history of hypertension, and number of siblings and children.

Conclusion
Although familial factors may be important in some families, overall they account for few cases of subarachnoid hemorrhage.

Author Affiliations
From the Department of Epidemiology, Tianjin (China) Medical College (Dr Wang), and the Division of Neurology, Department of Medicine, School of Medicine (Dr Longstreth), and the Department of Epidemiology, School of Public Health and Community Medicine (Drs Longstreth and Koepsell), University of Washington, Seattle.

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