Idiopathic Intracranial HypertensionLack of Histologic Evidence for Cerebral Edema
Michael Wall, MD;
James D. Dollar, MD;
Alfredo A. Sadun, PhD, MD;
Randy Kardon, PhD, MD
Arch Neurol. 1995;52(2):141-145.
Abstract
Objective
To study brain histologic features in two cases of idiopathic intracranial hypertension (pseudotumor cerebri) at autopsy.
Design
Formaldehyde solution—fixed sections of cerebral white matter in two cases and structures of the sensory visual system in one case were analyzed.
Setting
University medical center.
Patients
Two patients with idiopathic intracranial hypertension who died unexpectedly.
Main Outcome Measure
Histologic study of cerebral white matter in the two patients.
Results
We did not find histologic evidence of any type of cerebral edema in our patients. Review of a portion of the material from a previous report is also consistent with this conclusion.
Conclusion
If patients with idiopathic intracranial hypertension have histologically apparent cerebral edema, it is not a consistent finding.
Author Affiliations
From the Departments of Neurology (Dr Wall), Ophthalmology (Drs Wall and Kardon), and Pathology (Dr Dollar), University of Iowa, College of Medicine, Iowa City; and the Department of Ophthalmology (Dr Sadun), University of Southern California, School of Medicine, Los Angeles.
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