 |
|
The Relationship of Neuropsychological Functioning to Quality of Life in Epilepsy
Kenneth Perrine, PhD;
Bruce P. Hermann, PhD;
Kimford J. Meador, MD;
Barbara G. Vickrey, MD, MPH;
Joyce A. Cramer;
Ron D. Hays, PhD;
Orrin Devinsky, MD
Arch Neurol. 1995;52(10):997-1003.
Abstract
| |
Objective
To examine the relationship of objectively assessed cognitive functioning to self-reported quality of life.
Design
Correlational, multiple regression, and factor analytic comparisons of a new self-report quality of life inventory with neuropsychological tests of cognition and mood.
Subjects
Two hundred fifty-seven patients with epilepsy.
Setting
Twenty-five epilepsy centers and neurology clinics across the United States.
Measures
A recently developed self-report (ie, Quality of Life in Epilepsy—89 inventory) and objective tests of memory, verbal abilities, spatial functions, psychomotor and cognitive processing speed, cognitive flexibility, and mood.
Results
Factors that assessed mood, psychomotor speed, verbal memory, and language correlated significantly with selected scales of the Quality of Life in Epilepsy—89 inventory (P<.0001) and were predictive of overall quality of life (P<.002 to P<.0001). The mood factor showed the highest correlations (r=–.20 to r=–.73) and was the strongest predictor of quality of life in regression analyses (46.7% explained variance, P<.0001).
Conclusions
Mood may be adversely affected by diminished quality of life, or perceived quality of life may be affected by mood disturbance. Quantitative quality of life assessments can be used in conjunction with formal neuropsychological testing of mood and cognition when evaluating patients with epilepsy.
Author Affiliations
From the Department of Neurology, New York (NY) University School of Medicine and Hospital for Joint Diseases (Drs Perrine and Devinsky); the Departments of Psychiatry and Neurosurgery, University of Tennessee and Epi-Care Center, Memphis (Dr Hermann); the Department of Neurology, Medical College of Georgia, Augusta (Dr Meador); the Department of Neurology, School of Medicine, University of California—Los Angeles (Dr Vickrey); the Department of Social Policy, RAND, Santa Monica, Calif (Drs Vickrey and Hays); and Health Services Research, West Haven (Conn) Veterans Affairs Medical Center (Ms Cramer).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
How skeptical should we be about industry-sponsored studies?
Meador and Chadwick
Neurology 2007;68:1238-1238.
FULL TEXT
Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy
Boylan et al.
Neurology 2004;62:258-261.
ABSTRACT
| FULL TEXT
Initial outcomes in the Multicenter Study of Epilepsy Surgery
Spencer et al.
Neurology 2003;61:1680-1685.
ABSTRACT
| FULL TEXT
The co-morbidity of depression and epilepsy: Epidemiology, etiology, and treatment
Harden
Neurology 2002;59:S48-55.
ABSTRACT
| FULL TEXT
Optimizing health outcomes in active epilepsy
Gilliam
Neurology 2002;58:S9-20.
ABSTRACT
| FULL TEXT
Psychiatric aspects of temporal lobe epilepsy before and after anterior temporal lobectomy
Glosser et al.
J. Neurol. Neurosurg. Psychiatry 2000;68:53-58.
ABSTRACT
| FULL TEXT
Subjective versus objective memory change after temporal lobe epilepsy surgery
Sawrie et al.
Neurology 1999;53:1511-1511.
ABSTRACT
| FULL TEXT
Quality of Life Perception in Patients With Intractable Epilepsy or Pseudoseizures
Breier et al.
Arch Neurol 1998;55:660-665.
ABSTRACT
| FULL TEXT
The Clinician-Scientist in Neuropsychiatry: A Position Statement From the Committee on Research of the American Neuropsychiatric Association
Cummings et al.
J. Neuropsychiatry Clin. Neurosi. 1998;10:1-9.
ABSTRACT
| FULL TEXT
Epilepsy
Dodrill and Batzel
Arch Neurol 1996;53:476-476.
ABSTRACT
Epilepsy-Reply
Perrine et al.
Arch Neurol 1996;53:476-477.
ABSTRACT
|
