This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal

I. Initial Therapy in 17 Neurologically Affected Patients

George J. Brewer, MD; Robert D. Dick; Virginia Johnson, MS; Yuxun Wang; Vilma Yuzbasiyan-Gurkan, PhD; Karen Kluin, MS; John K. Fink, MD; Alex Aisen, MD

Arch Neurol. 1994;51(6):545-554.

Abstract
Objective
To test the efficacy and toxicity of a new drug, ammonium tetrathiomolybdate, in the initial treatment of a relatively large series of patients presenting with neurologic signs and symptoms caused by Wilson's disease. The key aspect of efficacy was to preserve the neurologic function present at the onset of therapy.

Design
An open study of 17 patients treated for 8 weeks each. Neurologic function was evaluated by frequent quantitative neurologic and speech examinations. Several copper-related variables were studied to evaluate the effect of the drug on copper, and a large number of biochemical and clinical variables were studied to evaluate potential toxicity. Patients were then followed up at yearly intervals, with follow-up periods of 1 to 5 years reported.

Setting
A university hospital referral setting.

Intervention
Patients were generally treated for 8 weeks with tetrathiomolybdate, followed by zinc maintenance therapy.

Main Outcome Measures
Neurologic function was evaluated by quantitative neurologic and speech examinations.

Results
None of the patients suffered a loss of neurologic function. Copper status and potential further toxic effects were generally well controlled quickly. No toxic effects resulted from administration of tetrathiomolybdate. During the ensuing period of follow-up of 1 to 5 years, neurologic recovery in most patients was good to excellent.

Conclusions
Tetrathiomolybdate appears to be an excellent form of initial treatment in patients with Wilson's disease presenting with neurologic signs and symptoms. In contrast to penicillamine therapy, initial treatment with tetrathiomolybdate does not result in further, often irreversible neurologic deterioration.

Author Affiliations
From the Departments of Human Genetics (Drs Brewer and Yuzbasiyan-Gurkan, Messrs Dick and Wang, and Ms Johnson), Internal Medicine (Dr Brewer), Division of Speech Pathology, Department of Physical Medicine and Rehabilitation (Ms Kluin), Neurology (Ms Kluin and Dr Fink), and Radiology (Dr Aisen), The University of Michigan Medical School, Ann Arbor.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Tetrathiomolybdate Is Partially Protective Against Hyperglycemia in Rodent Models of Diabetes
Zeng et al.
Exp. Biol. Med. 2008;233:1021-1025.
ABSTRACT | FULL TEXT  

Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes
de Bie et al.
J. Med. Genet. 2007;44:673-688.
ABSTRACT | FULL TEXT  

Treatment of Wilson Disease With Ammonium Tetrathiomolybdate: IV. Comparison of Tetrathiomolybdate and Trientine in a Double-blind Study of Treatment of the Neurologic Presentation of Wilson Disease.
Brewer et al.
Arch Neurol 2006;63:521-527.
ABSTRACT | FULL TEXT  

Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer
Redman et al.
Clin. Cancer Res. 2003;9:1666-1672.
ABSTRACT | FULL TEXT  

Treatment of Wilson Disease With Ammonium Tetrathiomolybdate: III. Initial Therapy in a Total of 55 Neurologically Affected Patients and Follow-up With Zinc Therapy
Brewer et al.
Arch Neurol 2003;60:379-385.
ABSTRACT | FULL TEXT  

Copper Control as an Antiangiogenic Anticancer Therapy: Lessons from Treating Wilson's Disease
Brewer
Exp. Biol. Med. 2001;226:665-673.
ABSTRACT | FULL TEXT  

Recognition, Diagnosis, and Management of Wilson's Disease
Brewer
Exp. Biol. Med. 2000;223:39-46.
ABSTRACT | FULL TEXT  

Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Antiangiogenic Agent: Phase I Study
Brewer et al.
Clin. Cancer Res. 2000;6:1-10.
ABSTRACT | FULL TEXT  

Experiments That Changed Nutritional Thinking
Carpenter et al.
J. Nutr. 1997;127 :1017S-1017S.
FULL TEXT  

Treatment of the Neurologic Manifestations of Wilson's Disease
Scheinberg and Sternlieb
Arch Neurol 1995;52:339-340.
ABSTRACT  

Treatment of the Neurologic Manifestations of Wilson's Disease-Reply
Brewer
Arch Neurol 1995;52:340-340.
ABSTRACT