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Neuropathologic Correlations

Jeff Victoroff, MD; G. Webster Ross, MD; D. Frank Benson, MD; M. Anthony Verity, MD; Harry V. Vinters, MD

Arch Neurol. 1994;51(3):269-274.

Abstract
Objective
A subgroup of patients with progressive dementia has been reported with a marked predominance of symptoms attributed to the dysfunction of the posterior parieto-occipital cortex. These cases have been referred to as posterior cortical atrophy. The objective of this study was to determine whether posterior cortical atrophy is associated with distinct, uniform neuropathologic findings.

Design
Three individuals with progressive dementia that began with higher visual dysfunction (posterior cortical atrophy) were followed up to definitive neuropathologic diagnosis.

Results
Three separate neuropathologic entities were discovered: subcortical gliosis, Alzheimer's disease, and Creutzfeldt-Jakob disease.

Conclusion
Posterior cortical atrophy is a clinically homogeneous but pathologically heterogeneous syndrome.

Author Affiliations
From the Departments of Neurology (Drs Victoroff, Ross, and Benson) and Pathology (Neuropathology Division) (Drs Verity and Vinters), UCLA School of Medicine, Los Angeles, Calif. Dr Victoroff is now with the Department of Neurology, University of Southern California School of Medicine, Rancho Los Amigos Medical Center, Downey, Calif.

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