This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Jeff I. Victoroff, MD; D. Frank Benson, MD; Scott T. Grafton, MD; Jerome Engel, Jr, MD, PhD; John C. Mazziotta, MD, PhD

Arch Neurol. 1994;51(2):155-163.

Abstract
Objective
We sought to determine whether the frequency of depressive disorders among patients with complex partial seizures is associated with the laterality of ictal onset or the laterality of interictal cerebral hypometabolism.

Design
Fifty-three patients with medically intractable complex partial seizures were assessed for history of interictal depressive disorders meeting strict Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R), criteria with use of a modification of the Structured Clinical Interview for DSM-III-R. All subjects underwent video-electroencephalographic telemetry and fludeoxyglucose F 18 positron emission tomographic scanning. The main outcome measure was the frequency of a history of major depressive episodes (MDEs) in subjects with left-sided vs right-sided ictal onset and in subjects with left-sided vs right-sided temporal lobe hypometabolism.

Results
Thirty-three subjects (62%) had a history of interictal depressive disorders, 16 (30%) of whom met criteria for one or more MDEs. More of those with left-sided ictal onset had a history of depression. Thirty-six subjects had definite unilateral temporal lobe hypometabolism demonstrated by positron emission tomographic scanning. More of those with left temporal lobe hypometabolism had a history of MDEs, and the combination of left temporal lobe hypometabolism and high-degree hypometabolism was strongly associated with a history of MDEs. Furthermore, among those with right temporal lobe hypometabolism, more of those with high-degree hypometabolism had a history of MDEs.

Conclusion
Laterality of ictal onset and degree of interictal temporal lobe hypometabolism may be interdependent factors that contribute to the risk of depressive disorder in patients with complex partial seizures.

Author Affiliations
From the Departments of Neurology, University of Southern California School of Medicine (Drs Victoroff and Grafton), and the Departments of Neurology (Drs Benson, Engel, and Mazziotta) and Anatomy and Cell Biology (Dr Engel) and the Brain Research Institute (Dr Engel), UCLA School of Medicine, Los Angeles, Calif.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Review: Depression in epilepsy: mechanisms and therapeutic approach
Mula and Schmitz
Therapeutic Advances in Neurological Disorders 2009;2:337-344.
ABSTRACT  

Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study
Lothe et al.
Brain 2008;131:2765-2782.
ABSTRACT | FULL TEXT  

Neuropsychiatric morbidity in focal epilepsy
Adams et al.
Br. J. Psychiatry 2008;192:464-469.
ABSTRACT | FULL TEXT  

Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy
Gilliam et al.
Neurology 2007;68:364-368.
ABSTRACT | FULL TEXT  

Mood Disorders and Their Treatment in Patients With Epilepsy
Prueter and Norra
J. Neuropsychiatry Clin. Neurosi. 2005;17:20-28.
ABSTRACT | FULL TEXT  

The co-morbidity of depression and epilepsy: Epidemiology, etiology, and treatment
Harden
Neurology 2002;59:S48-55.
ABSTRACT | FULL TEXT  

Depression and epilepsy: How closely related are they?
Kanner and Balabanov
Neurology 2002;58:S27-39.
ABSTRACT | FULL TEXT  

Lesion pattern in patients with multiple sclerosis and depression
Berg et al.
Mult Scler 2000;6:156-162.
ABSTRACT  

The Psychiatric Perspectives of Epilepsy
Schwartz and Marsh
Psychosomatics 2000;41:31-38.
ABSTRACT | FULL TEXT  

Temporal Lobe Epilepsy, Temporal Lobectomy, and Major Depression
Altshuler et al.
J. Neuropsychiatry Clin. Neurosi. 1999;11:436-443.
ABSTRACT | FULL TEXT  

Personality Disorders Among Medically Refractory Epileptic Patients
Lopez-Rodriguez et al.
J. Neuropsychiatry Clin. Neurosi. 1999;11:464-469.
ABSTRACT | FULL TEXT  

Metamemory in Temporal Lobe Epilepsy
Deutsch et al.
Assessment 1996;3:255-263.
ABSTRACT  

Functional Neuroimaging With SPECT in Children With Partial Epilepsy
Harvey and Berkovic
J Child Neurol 1994;9:S71-S81.
ABSTRACT