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Lawrence Jacobs, MD; Kenneth P. Johnson, MD

Arch Neurol. 1994;51(12):1245-1252.

Abstract
Interferons (IFNs) are a family of glycoproteins that are naturally secreted by certain cells in response to viral infection. The naturally occurring IFNs confer protection on other cells, preventing them from becoming infected, a phenomenon referred to as "virus interference" by Isaacs and Lindenmann¹ in the first description of these proteins. In addition to their antiviral properties, the IFNs also have complex immunomodulatory, antiproliferative, and hormonelike activities, which are not completely understood.²⁴

Author Affiliations
From the Departments of Neurology, University at Buffalo (NY) (Dr Jacobs) and University of Maryland, Baltimore (Dr Johnson).

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