This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (21)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Carmelo Graffagnino, MD, FRCPC; Michael H. Herbstreith; Allen D. Roses, MD; Mark J. Alberts, MD

Arch Neurol. 1994;51(10):981-984.

Abstract
Background
Two forms of inherited intracerebral hemorrhage (ICH) are associated with an amyloid angiopathy caused by mutations in the genes for the amyloid precursor protein or cystatin C. The purpose of this study was to determine whether patients with sporadic ICH have mutations in the amyloid precursor protein or cystatin C genes.

Methods
Consecutive patients with ICH admitted to the neurology or neurosurgery services at Duke University Hospital, Durham, NC, were studied. Using the polymerase chain reaction, we amplified exons 16 and 17 of the amyloid precursor protein and exon 2 of cystatin C and sequenced the products. Twenty-six men and 22 women were studied. The ICH location was deep in 29 patients, lobar in 16, cerebellar in two, and brain stem in one. There were 30 patients (63%) with a positive family history of stroke; seven of them (15%) had a family history of ICH.

Conclusions
Mutations previously reported to cause familial forms of ICH were not found in this group of patients.

Author Affiliations
From the Division of Neurology, Department of Medicine (Drs Graffagnino, Roses, and Alberts and Mr Herbstreith), Department of Neurobiology (Dr Roses), and Stroke Acute Care Unit (Dr Alberts), Duke University Medical Center, Durham, NC.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Is hypertension a more frequent risk factor for deep than for lobar supratentorial intracerebral haemorrhage?
Jackson and Sudlow
J. Neurol. Neurosurg. Psychiatry 2006;77:1244-1252.
ABSTRACT | FULL TEXT  

Absence of cystatin C mutation in sporadic cerebral amyloid angiopathy-related hemorrhage
McCarron et al.
Neurology 2000;54:242-242.
ABSTRACT | FULL TEXT  

Cerebral Amyloid Angiopathy–Related Hemorrhage : Interaction of APOE {epsilon}2 With Putative Clinical Risk Factors
McCarron et al.
Stroke 1999;30:1643-1646.
ABSTRACT | FULL TEXT  

Recurrent cerebral haemorrhage in a 65 year old man: advanced clinical neurology course, Edinburgh, 1997
Weir et al.
J. Neurol. Neurosurg. Psychiatry 1999;66:104-110.
FULL TEXT  

Cystatin C Mutation in an Elderly Man With Sporadic Amyloid Angiopathy and Intracerebral Hemorrhage
Graffagnino et al.
Stroke 1995;26:2190-2193.
ABSTRACT | FULL TEXT  

Neurology
Joynt
JAMA 1995;273:1695-1697.
ABSTRACT