 |
|
Posterior Neocortical Systems Subserving Awareness and NeglectNeglect Associated With Superior Temporal Sulcus but Not Area 7 Lesions
Robert T. Watson, MD;
Edward Valenstein, MD;
Arthur Day, MD;
Kenneth M. Heilman, MD
Arch Neurol. 1994;51(10):1014-1021.
Abstract
| |
Objective
In humans and monkeys, the intraparietal sulcus separates the superior parietal lobule from the inferior parietal lobule (IPL). Whereas in humans Brodmann's area 7 is above this sulcus, in monkeys it is below and therefore part of the IPL. In humans, the IPL consists of Brodmann's areas 39 and 40. Some investigators contend that the monkey homologue of the human IPL (areas 39 and 40) is the monkey's IPL (area 7). Others contend that it is, at least in part, in the monkey's superior temporal sulcus (STS). In humans, IPL lesions induce neglect. Although IPL lesions in monkeys also have been reported to induce neglect, the STS was involved in these lesions. We sought to learn which of these two areas, when ablated, produces neglect.
Design
Study of five adult stump-tailed macaque monkeys by making five isolated STS and six IPL lesions.
Results
Inferior parietal lobule lesions were associated with misreaching but not with unilateral neglect. Neglect was observed in association with five of the six STS lesions.
Conclusions
With regard to neglect, STS may be the monkey homologue of the human IPL. Animals with STS lesions and humans with IPL lesions may manifest unilateral neglect because these areas are necessary for normal awareness of external stimuli. This awareness may result from the integration of the areas important in stimulus localization (the "where is it?" system) and stimulus identification (the "what is it?" system), as well as the areas important in defining the biologic importance of stimuli, such as the frontal lobes and limbic areas.
Author Affiliations
From the Neurology Service, Veterans Affairs Medical Center (Drs Watson and Heilman), and the Department of Neurosurgery (Dr Day) and the Center for Neuropsychological Studies, Department of Neurology (Drs Watson, Valenstein, and Heilman), University of Florida College of Medicine, Gainesville.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Delineation of the Middle Longitudinal Fascicle in Humans: A Quantitative, In Vivo, DT-MRI Study
Makris et al.
Cereb Cortex 2009;19:777-785.
ABSTRACT
| FULL TEXT
Audio-Visual Multisensory Integration in Superior Parietal Lobule Revealed by Human Intracranial Recordings
Molholm et al.
J. Neurophysiol. 2006;96:721-729.
ABSTRACT
| FULL TEXT
Spatial neglect--a vestibular disorder?
Karnath and Dieterich
Brain 2006;129:293-305.
ABSTRACT
| FULL TEXT
Cortical Control of Visually Guided Reaching: Evidence from Patients with Optic Ataxia
Karnath and Perenin
Cereb Cortex 2005;15:1561-1569.
ABSTRACT
| FULL TEXT
Anatomy of Spatial Attention: Insights from Perfusion Imaging and Hemispatial Neglect in Acute Stroke
Hillis et al.
J. Neurosci. 2005;25:3161-3167.
ABSTRACT
| FULL TEXT
The Anatomy of Spatial Neglect based on Voxelwise Statistical Analysis: A Study of 140 Patients
Karnath et al.
Cereb Cortex 2004;14:1164-1172.
ABSTRACT
| FULL TEXT
Animal Models of Cerebral Neglect and Its Cancellation
Payne and Rushmore
Neuroscientist 2003;9:446-454.
ABSTRACT
Prism adaptation treatment of neglect: Conflicting results?
Beversdorf and Heilman
Neurology 2003;60:1734-1735.
FULL TEXT
Anatomical Evidence of Multimodal Integration in Primate Striate Cortex
Falchier et al.
J. Neurosci. 2002;22:5749-5759.
ABSTRACT
| FULL TEXT
A large-scale distributed network for covert spatial attention: Further anatomical delineation based on stringent behavioural and cognitive controls
Gitelman et al.
Brain 1999;122:1093-1106.
ABSTRACT
| FULL TEXT
|
