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Normal Activation of Frontotemporal Language Cortex in Dyslexia, as Measured With Oxygen 15 Positron Emission Tomography
Judith M. Rumsey, PhD;
Alan J. Zametkin, MD;
Paul Andreason, MD, MS;
Ashley P. Hanahan, MPH;
Susan D. Hamburger, MA;
Tracy Aquino, MA;
A. Catherine King;
Anita Pikus, MA;
Robert M. Cohen, MD, PhD
Arch Neurol. 1994;51(1):27-38.
Abstract
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Objective
To assess the ability of dyslexic men to activate left middle to anterior language cortex normally.
Design
Positron emission tomography using oxygen 15—labeled water as a tracer during rest and during a syntax task involving sentence comprehension.
Setting
Research hospital.
Patients or Other Participants
Fifteen right-handed, severely dyslexic men (mean [±SD] age, 27±5 years) and 20 matched controls.
Interventions
None.
Main Outcome Measure
Cerebral blood flow.
Results
During rest, dyslexics showed reduced blood flow (relative to controls) in one left parietal region near the angular/supramarginal gyri, but otherwise normal flow. During syntactic processing, dyslexics and controls showed similar, significant activation of left middle to anterior temporal and inferior frontal cortex.
Conclusions
These results, together with the previously reported failure of dyslexics to activate left temporoparietal cortex during phonologic processing, argue for dysfunction of left cortical language areas restricted to posterior language regions in dyslexia.
Author Affiliations
From the Child Psychiatry Branch (Dr Rumsey and Mss Hanahan, Hamburger, Aquino, and King) and the Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism (Drs Zametkin, Andreason, and Cohen), National Institute of Mental Health, and the Clinical Audiology, Hearing Section, National Institute on Deafness and Communication Disorders (Ms Pikus), Bethesda, Md.
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