Amygdala atrophy in Alzheimer's disease. An in vivo magnetic resonance imaging study
C. A. Cuenod, A. Denys, J. L. Michot, P. Jehenson, F. Forette, D. Kaplan, A. Syrota and F. Boller
Frederic-Joliot Hospital, Atomic Energy Commission, Orsay, France.
OBJECTIVES--To study the ability of magnetic resonance imaging to measure
the volume of the amygdala and detect amygdala atrophy in patients with
early Alzheimer's disease. DESIGN--Prospective case-control study and
"blind" measurements. SETTING--Subjects were ambulatory outpatients
selected from an institutional practice in Paris, France. PATIENTS--We
studied 11 patients with probable Alzheimer's disease according to National
Institute of Neurologic and Communicative Disorders and Stroke/Alzheimer's
Disease and Related Disorders Association (NINCDS-ADRDA) and Consortium to
Establish a Registry for Alzheimer's Disease (CERAD) inclusion and
exclusion criteria, as well as six age-matched control subjects.
INTERVENTION--None. MAIN OUTCOME MEASURE--A 1.5-T magnetic resonance imager
was used to acquire the images. Two neuroradiologists independently and
blindly measured the volume of the right and left amygdalas on
high-resolution contiguous slices. In addition, other cerebral structures,
ie, the sylvian fissures, temporal lobes, lateral and third ventricles,
corpus callosum, and hippocampal formation, were measured on a single
slice. RESULTS--The values obtained by the two observers correlated highly
(r = .90), and interrater variability was 13%. The Alzheimer's disease
group showed significant (33%, P < .0001) atrophy of the amygdala when
compared with the control group. The other structures showed less
variation. CONCLUSION--Significant amygdala atrophy can be detected in vivo
in patients with early Alzheimer's disease by means of standard magnetic
resonance imaging. This technique may be useful in the early diagnosis of
Alzheimer's disease.
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