This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Jamie L. Eberling, PhD; Bruce R. Reed, PhD; Michael G. Baker, MA; William J. Jagust, MD

Arch Neurol. 1993;50(7):761-766.

Abstract
• Objective.
—To study the relationship between relative regional cerebral blood flow (rCBF) and performance on a variety of neuropsychological tests in a group of subjects with Alzheimer's disease.

Design.
—Analysis of the relationship between relative rCBF and neuropsychological performance using stepwise multiple regressions and Pearson Product-Moment Correlation coefficients.

Setting.
—University dementia clinic and research laboratory.

Participants.
—Twelve mildly demented patients with Alzheimer's disease (Mini-Mental State examination [MMSE] scores, 24 to 29; age, 56 to 78 years); 38 moderately demented patients with Alzheimer's disease (MMSE scores, 0 to 23; age, 59 to 86 years); and eight normal control subjects (MMSE scores, 27 to 30; age, 61 to 79 years).

Main Outcome Measures.
—Single photon emission computed tomography and the blood flow tracer N-isopropylp-iodoamphetamine iodine 123 were used to measure relative rCBF. Cognitive performance was assessed by grouping neuropsychological tests into clusters reflecting frontal lobe abilities, perseveration, memory, and visuoconstructive abilities.

Results.
—While MMSE score was a significant (P<.05) predictor of visuoconstruction, frontal lobe, and memory cluster scores, relative rCBF was a weaker predictor of neuropsychological performance, with only right orbitofrontal relative rCBF emerging as a significant (P<.05) predictor of the frontal cluster score and right parietal relative rCBF as a significant (P<.05) predictor of the visuoconstruction cluster score.

Conclusions.
—These results support our a priori grouping of neuropsychological tests into frontal and visuoconstruction clusters and suggest that these two clusters are good measures of frontal and parietal lobe function, respectively.

Author Affiliations
From the Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California, Berkeley (Dr Eberling); the Department of Neurology, University of California, Davis; and the University of California, Davis, Alzheimer's Disease Center (Drs Eberling, Reed, and Jagust and Mr Baker).

Footnotes
Accepted for publication December 8, 1992.

Reprint requests to Center for Functional Imaging, 55-121, Lawrence Berkeley Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720 (Dr Eberling).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Executive Dysfunction in Alzheimer's Disease: Association With Neuropsychiatric Symptoms and Functional Impairment
Chen et al.
J. Neuropsychiatry Clin. Neurosi. 1998;10:426-432.
ABSTRACT | FULL TEXT  

Temporal Lobe Perfusion on Single Photon Emission Computed Tomography Predicts the Rate of Cognitive Decline in Alzheimer's Disease
Wolfe et al.
Arch Neurol 1995;52:257-262.
ABSTRACT