 |
|
Silent Brain Infarction and Coronary Artery Disease in Japanese Patients
Hidekazu Tanaka, MD;
Kenji Sueyoshi, PhD, MD;
Masami Nishino, MD;
Mariko Ishida, MD;
Ryuzo Fukunaga, PhD, MD;
Hiroshi Abe, PhD, MD
Arch Neurol. 1993;50(7):706-709.
Abstract
• Objective.
—Silent brain infarction is fairly common in the elderly, but predictive factors have not been definitively established. This study focuses attention on ischemic heart disease and cerebrovascular risk factors about the frequency of silent brain infarction.
Design.
—The existence of silent brain infarction, the extent of coronary artery stenosis, and cerebrovascular risk factors of consecutive 92 case series with suspected ischemic heart disease were surveyed.
Setting.
—A hospital for patients with ischemic heart disease.
Patients.
—Ninety-two consecutive Japanese patients with suspected ischemic heart disease were recruited.
Main Outcome Measures.
—All subjects were evaluated for coronary atherosclerosis (number of coronary arteries with significant stenosis and Gensini score), the number of silent brain infarctions detected by computed tomography, the extent of carotid atherosclerosis as determined by B-mode ultrasonography, and cerebrovascular risk factors.
Results.
—Patients with silent cerebral infarctions were older (66.2±10.4 years) than those without such events (60.1±8.8 years) (P<.01). The extent of coronary atherosclerosis in patients with silent cerebral infarctions was significantly greater than in those without such events after adjustment for the effect of age (P<.001). The extent of carotid atherosclerosis and the percentages of individuals with hypertension, diabetes mellitus, a smoking habit, hypercholesterolemia, hypertriglyceridemia, and a low serum high-density lipoprotein cholesterol level did not differ between the groups with and without silent brain infarction. The frequency of silent brain infarction increased with the severity of coronary stenosis.
Conclusion.
—Coronary atherosclerosis and age were important risk factors for silent brain infarction.
Author Affiliations
From the First Department of Internal Medicine, Osaka (Japan) Rosai Hospital.
Footnotes
Accepted for publication November 20, 1992.
Reprint requests to First Department of Internal Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565, Japan (Dr Tanaka).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Risk factors of stroke and delirium after off-pump coronary artery bypass surgery
Miyazaki et al.
Interact CardioVasc Thorac Surg 2011;12:379-383.
ABSTRACT
| FULL TEXT
Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction in Healthy People
Kwon et al.
Stroke 2006;37:466-470.
ABSTRACT
| FULL TEXT
Effect of Intravenous Dipyridamole on Cerebral Blood Flow in Humans : A PET Study
Ito et al.
Stroke 1999;30:1616-1620.
ABSTRACT
| FULL TEXT
Risk Factors for Silent Cerebral Infarcts in Subcortical White Matter and Basal Ganglia
Uehara et al.
Stroke 1999;30:378-382.
ABSTRACT
| FULL TEXT
Prevalence and Associations of MRI-Demonstrated Brain Infarcts in Elderly Subjects With a History of Transient Ischemic Attack : The Cardiovascular Health Study
Bhadelia et al.
Stroke 1999;30:383-388.
ABSTRACT
| FULL TEXT
Silent Brain Infarction on Magnetic Resonance Imaging and Neurological Abnormalities in Community-Dwelling Older Adults : The Cardiovascular Health Study
Price et al.
Stroke 1997;28:1158-1164.
ABSTRACT
| FULL TEXT
Asymptomatic Occlusive Lesions of Carotid and Intracranial Arteries in Japanese Patients With Ischemic Heart Disease : Evaluation by Brain Magnetic Resonance Angiography
Uehara et al.
Stroke 1996;27:393-397.
ABSTRACT
| FULL TEXT
|
