Serum lipid levels during carbamazepine medication. A prospective study
J. I. Isojarvi, A. J. Pakarinen and V. V. Myllyla
Department of Neurology, University of Oulu, Finland.
OBJECTIVE--The aim of the study was to evaluate serum lipid levels during
carbamazepine medication. DESIGN--A 5-year prospective follow-up study.
SETTING--Outpatient department, University Central Hospital of Oulu
(Finland). PATIENTS--Thirty-six consecutive untreated patients with
recently diagnosed idiopathic epilepsy. All patients completed the 1-year
follow-up, and 19 patients completed the 5-year follow-up.
INTERVENTIONS--The patients were treated with carbamazepine for their newly
diagnosed seizure disorder. MAIN OUTCOME MEASURES--Serum lipid levels were
followed up during the medication use. RESULTS--Serum total cholesterol and
high-density lipoprotein cholesterol concentrations increased after 2
months of treatment with carbamazepine and remained high after 1 and 5
years. Furthermore, concentrations of serum low-density lipoprotein
cholesterol and triglycerides increased transiently during the first year
of medication. The increase in serum total cholesterol levels correlated
with an increase in serum gamma-glutamyltransferase concentrations.
CONCLUSIONS--Serum lipid levels change during carbamazepine medication; the
increase in serum concentrations of total cholesterol and high-density
lipoprotein cholesterol seems permanent, but the increase in serum
low-density lipoprotein cholesterol and triglyceride levels is transient.
The change in lipid metabolism may be associated with induction of the
liver enzymes during carbamazepine medication. The increase in serum
cholesterol and high-density lipoprotein cholesterol levels may have
clinical relevance with regard to the incidence of atherosclerosis and
coronary heart disease in patients with epilepsy receiving carbamazepine
medication.
Lipid Profile, Apolipoproteins A and B in Children With Epilepsy
Tomoum et al.
J Child Neurol 2008;23:1275-1281.
ABSTRACT
Evolution of Serum Lipids and Lipoprotein (a) Levels in Epileptic Children Treated With Carbamazepine, Valproic Acid, and Phenobarbital
Castro-Gago et al.
J Child Neurol 2006;21:48-53.
ABSTRACT
Possible Induction of Cholinesterase in Epileptic Patients Treated With Anticonvulsant Drugs: Relationship With Lipoprotein Levels
Tutor-Crespo et al.
J Clin Pharmacol 2004;44:974-980.
ABSTRACT
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Fasting serum insulin and lipid levels in men with epilepsy
Pylvanen et al.
Neurology 2003;60:571-574.
ABSTRACT
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Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults
Bramswig et al.
Am. J. Physiol. Heart Circ. Physiol. 2002;282:H704-H716.
ABSTRACT
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Effect of Antiepileptic Drugs on Plasma Lipoprotein (a) and Other Lipid Levels in Childhood
Mujgan Aynaci et al.
J Child Neurol 2001;16:367-369.
ABSTRACT
Oxcarbazepine Versus Carbamazepine Treatment and Induction of Serum Lipid Abnormalities
Papacostas
J Child Neurol 2000;15:138-140.
ABSTRACT
NALTREXONE EXERTS A FAVOURABLE EFFECT ON PLASMA LIPIDS IN ABSTINENT PATIENTS WITH ALCOHOL DEPENDENCE
Budzynski et al.
Alcohol Alcohol 2000;35:91-97.
ABSTRACT
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