This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Thomas R. Henry, MD; John C. Mazziotta, MD, PhD; Jerome Engel, Jr, MD, PhD

Arch Neurol. 1993;50(6):582-589.

Abstract
• Objective.
—To examine patterns of temporal and extratemporal regional interictal glucose hypometabolism in individual patients with unilateral mesial temporal lobe epilepsy (TLE). Previous reports disagree on which extratemporal areas can be hypometabolic in TLE.

Design.
—Case series of patients with TLE who underwent interictal fludeoxyglucose F 18 positron emission tomography, compared quantitatively with normal positron emission tomography.

Setting.
—Patients referred for surgical treatment of medically refractory complex partial seizures.

Patients and Other Participants.
—Ten normal volunteers; 27 patients with TLE selected to exclude seizures of bilateral temporal or extratemporal onset.

Results.
—Regional hypometabolism occurred in 25 patients. Hypometabolic regions were ipsilateral to seizure onset and included lateral temporal (in 78% of patients), mesial temporal (70%), thalamic (63%), basal ganglial (41%), frontal (30%), parietal (26%), and occipital (4%). Specific patterns of temporal and extratemporal hypometabolism varied considerably across the TLE group.

Conclusions.
—Any of the previously reported anatomic areas of hypometabolism can occur in individual patients with TLE. The prevalence of thalamic hypometabolism suggests a pathophysiologic role for the thalamus in initiation or propagation of temporal lobe seizures or in the interictal cognitive dysfunction of TLE.

Author Affiliations
From the Department of Neurology, School of Medicine, University of Michigan, Ann Arbor (Dr Henry), and Departments of Neurology (Drs Mazziotta and Engel), Radiological Sciences (Dr Mazziotta), and Anatomy and Cell Biology (Dr Engel), School of Medicine, UCLA, Los Angeles, Calif.

Footnotes
Accepted for publication December 17, 1992.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Reduced Neocortical Thickness and Complexity Mapped in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Lin et al.
Cereb Cortex 2007;17:2007-2018.
ABSTRACT | FULL TEXT  

Longitudinal Changes in Cortical Glucose Hypometabolism in Children With Intractable Epilepsy
Benedek et al.
J Child Neurol 2006;21:26-31.
ABSTRACT  

Dystonic posturing in seizures of mesial temporal origin: Electroclinical and metabolic patterns
Rusu et al.
Neurology 2005;65:1612-1619.
ABSTRACT | FULL TEXT  

Postoperative alteration of cerebral glucose metabolism in mesial temporal lobe epilepsy
Joo et al.
Brain 2005;128:1802-1810.
ABSTRACT | FULL TEXT  

Epilepsy Surgery Outcome in Children With Tuberous Sclerosis Complex Evaluated With {alpha}-[11C]Methyl-L-Tryptophan Positron Emission Tomography (PET)
Kagawa et al.
J Child Neurol 2005;20:429-438.
ABSTRACT  

Involvement of the Basal Ganglia in Refractory Epilepsy: An 18F-Fluoro-L-DOPA PET Study Using 2 Methods of Analysis
Bouilleret et al.
JNM 2005;46:540-547.
ABSTRACT | FULL TEXT  

Structural abnormalities remote from the seizure focus: A study using T2 relaxometry at 3 T
Briellmann et al.
Neurology 2004;63:2303-2308.
ABSTRACT | FULL TEXT  

Metabolic changes and electro-clinical patterns in mesio-temporal lobe epilepsy: a correlative study
Chassoux et al.
Brain 2004;127:164-174.
ABSTRACT | FULL TEXT  

Why do Seizures Cause Loss of Consciousness?
Blumenfeld and Taylor
Neuroscientist 2003;9:301-310.
ABSTRACT  

Intracranial ictal onset zone in nonlesional lateral temporal lobe epilepsy on scalp ictal EEG
Lee et al.
Neurology 2003;61:757-764.
ABSTRACT | FULL TEXT  

Does Asymmetric Basal Ganglia or Thalamic Activation Aid in Seizure Foci Lateralization on Ictal SPECT Studies?
Sojkova et al.
JNM 2003;44:1379-1386.
ABSTRACT | FULL TEXT  

Differential Features of Metabolic Abnormalities Between Medial and Lateral Temporal Lobe Epilepsy: Quantitative Analysis of 18F-FDG PET Using SPM
Kim et al.
JNM 2003;44:1006-1012.
ABSTRACT | FULL TEXT  

Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy
Juhasz et al.
Neurology 2003;60:960-968.
ABSTRACT | FULL TEXT  

Ipsilateral thalamic MRI abnormality in an epilepsy patient
Scantlebury et al.
Neurology 2003;60:728-728.
FULL TEXT  

Evidence of Neuronal Injury Outside the Medial Temporal Lobe in Temporal Lobe Epilepsy: N-Acetylaspartate Concentration Reductions Detected with Multisection Proton MR Spectroscopic Imaging--Initial Experience
Vermathen et al.
Radiology 2003;226:195-202.
ABSTRACT | FULL TEXT  

Multisection Proton MR Spectroscopy for Mesial Temporal Lobe Epilepsy
Capizzano et al.
Am. J. Neuroradiol. 2002;23:1359-1368.
ABSTRACT | FULL TEXT  

Correlation Between PET and SISCOM in Temporal Lobe Epilepsy
Bouilleret et al.
JNM 2002;43:991-998.
ABSTRACT | FULL TEXT  

Perfusion SPECT Changes After Acute and Chronic Vagus Nerve Stimulation in Relation to Prestimulus Condition and Long-Term Clinical Efficacy
Van Laere et al.
JNM 2002;43:733-744.
ABSTRACT | FULL TEXT  

Ipsilateral thalamic MRI abnormality in an epilepsy patient
Nagasaka et al.
Neurology 2002;58:641-644.
ABSTRACT | FULL TEXT  

In vivo hippocampal glucose metabolism in mesial temporal lobe epilepsy
Knowlton et al.
Neurology 2001;57:1184-1190.
ABSTRACT | FULL TEXT  

Detection of Mesial Temporal Lobe Hypoperfusion in Patients with Temporal Lobe Epilepsy by Use of Arterial Spin Labeled Perfusion MR Imaging
Wolf et al.
Am. J. Neuroradiol. 2001;22:1334-1341.
ABSTRACT | FULL TEXT  

Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome
Juhasz et al.
Neurology 2001;56:1650-1658.
ABSTRACT | FULL TEXT  

Temporal Lobe Epilepsy: Qualitative Reading of
Capizzano et al.
Radiology 2001;218:144-151.
ABSTRACT | FULL TEXT  

Postoperative Changes in Cerebral Metabolism in Temporal Lobe Epilepsy
Spanaki et al.
Arch Neurol 2000;57:1447-1452.
ABSTRACT | FULL TEXT  

Significance of interictal bilateral temporal hypometabolism in temporal lobe epilepsy
Koutroumanidis et al.
Neurology 2000;54:1811-1821.
ABSTRACT | FULL TEXT  

Interictal 18FDG PET Findings in Temporal Lobe Epilepsy With Deja vu
Adachi et al.
J. Neuropsychiatry Clin. Neurosi. 1999;11:380-386.
ABSTRACT | FULL TEXT  

Early and Delayed MR and PET Changes after Selective Temporomesial Radiosurgery in Mesial Temporal Lobe Epilepsy
Regis et al.
Am. J. Neuroradiol. 1999;20:213-216.
ABSTRACT | FULL TEXT  

Interictal regional slow activity in temporal lobe epilepsy correlates with lateral temporal hypometabolism as imaged with 18FDG PET: neurophysiological and metabolic implications
Koutroumanidis et al.
J. Neurol. Neurosurg. Psychiatry 1998;65:170-176.
ABSTRACT | FULL TEXT  

Pattern of Interictal Hypometabolism in PET Scans With Fludeoxyglucose F 18 Reflects Prior Seizure Types in Patients With Mesial Temporal Lobe Seizures
Savic et al.
Arch Neurol 1997;54:129-136.
ABSTRACT