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Veikko Laulumaa, MD; Jyrki T. Kuikka, PhD; Hilkka Soininen, MD; Kim Bergström, MSc; Esko Länsimies, MD; Paavo Riekkinen, MD

Arch Neurol. 1993;50(5):509-512.

Abstract
• Objective.
—To test the usefulness of single photon emission computed tomography (SPECT) with iodobenzamide in imaging basal ganglia and to elucidate the postulated upward regulation of the striatal D₂ dopamine receptors in patients with early Parkinson's disease.

Design.
—Fourteen patients with Parkinson's disease and eight control subjects were investigated with SPECT using iodobenzamide labeled with iodine 123 as dopamine receptor ligand.

Setting.
—Neurological outpatient service at a university hospital in Kuopio, Finland.

Patients.
—Fourteen patients with recently diagnosed unilateral, unmedicated Parkinson's disease and eight healthy control subjects.

Results.
—The SPECT images revealed high uptake of iodobenzamide in the basal ganglia. In the patient group, the accumulation was more intense and the iodobenzamide affinity rate was significantly higher in the striatum contralateral to the parkinsonian symptoms. Also, the basal gangliacerebellum ratio was higher in the contralateral hemisphere. In the control group, no significant side-to-side differences were observed.

Conclusion.
—Iodobenzamide with SPECT imaging is useful in evaluating patients with Parkinson's disease. The results also suggest compensatory D₂ dopamine receptor upward regulation in the striatum of patients with early unmedicated Parkinson's disease.

Author Affiliations
From the Departments of Neurology (Dr Laulumaa) and Clinical Physiology (Drs Kuikka and Länsimies and Mr Bergström), Kuopio (Finland) University Hospital; and the Department of Neurology, University of Kuopio (Drs Soininen and Riekkinen).

Footnotes
Accepted for publication September 8, 1992.

Reprint requests to Department of Neurology, Kuopio University Hospital, Box 1777, SF-7021 Kuopio, Finland (Dr Laulumaa).

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